{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:06:09Z","timestamp":1792677969121,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prognostic implication of mildly reduced ejection fraction (mrEF) after acute myocardial infarction has not been clearly demonstrated. We investigated the long\u2010term risk of cardiovascular death and its predictors in patients with mrEF following acute myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 18\u2009668 patients who presented with acute myocardial infarction were included in 2 prospective, multicenter registries. The incidence of adverse cardiovascular events according to the left ventricular ejection fraction (EF) strata at index admission were evaluated. A score system consisting of clinical variables were developed to predict long\u2010term cardiovascular death in the mrEF group. There were 2548 patients with reduced EF (EF \u226440%), 4266 patients with mrEF (EF 41%\u201349%), and 11\u2009854 patients with preserved EF (EF \u226550%). During a median follow\u2010up period of 37.9 months, the cardiovascular death rate was 22.3% in the reduced EF group, 10.3% in the mrEF group, and 7.3% in the preserved EF group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In the mrEF group, age&gt;65\u2009years, hypertension, stroke, severe renal insufficiency, and Killip class \u22653 were independent predictors for cardiovascular death. Presence of &gt;2 predictors best discriminated the high\u2010risk patients for cardiovascular death with an area under the curve of 0.746. Incidence of cardiovascular death in the high\u2010risk mrEF group was comparable with the rEF group, while it was lower in the low\u2010risk mrEF group than in the pEF group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with mrEF after acute myocardial infarction had a modest risk of cardiovascular death. Clinical predictors could help discriminate a high\u2010risk subpopulation with cardiovascular death risks comparable with those in the reduced EF group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034870","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:17:31Z","timestamp":1725880651000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010Term Risk of Cardiovascular Death in Patients With Mildly Reduced Ejection Fraction After Acute Myocardial Infarction: A Multicenter, Prospective Registry Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8189-8689","authenticated-orcid":false,"given":"Hwajung","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-1046","authenticated-orcid":false,"given":"Kwan Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"},{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-3176","authenticated-orcid":false,"given":"Eun Ho","family":"Choo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"},{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong\u2010Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"},{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"},{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-8325","authenticated-orcid":false,"given":"Chan Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Uijeongbu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-8705","authenticated-orcid":false,"given":"Kiyuk","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea"},{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of 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