{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:17:48Z","timestamp":1789996668779,"version":"4.0.1"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with severe mitral regurgitation and cardiogenic shock demonstrate a poor prognosis. Mitral transcatheter edge\u2010to\u2010edge repair could alter patient management.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We systematically reviewed PubMed\/Medline, Scopus, and Cochrane Library until January 2023, including studies assessing transcatheter edge\u2010to\u2010edge repair in patients with severe mitral regurgitation and cardiogenic shock. Studies with &lt;5 patients were excluded. The primary outcome was device success and all\u2010cause death, while secondary outcomes included myocardial infarction, stroke, and heart failure hospitalization rates at 30\u2010day and intermediate\u2010term follow\u2010up. A fixed\u2010effects meta\u2010analysis was used to estimate pooled rates. Risk of bias was assessed with the Newcastle\u2013Ottawa Scale. A total of 24 studies and 5428 patients were included, with a mean age of 71.2\u00b13.3\u2009years and a high mean Society of Thoracic Surgery score (15.2\u00b18.9). Device success was achieved in 86% (95% CI, 85%\u201387%) and mitral regurgitation \u22642+ in 89% (95% CI: 88%\u201390%). The 30\u2010day all\u2010cause mortality rate was 14% (95% CI, 13%\u201315%). Stroke, myocardial infarction, and heart failure hospitalization rates were 2% (95% CI, 1%\u20132%), 15% (95% CI, 13%\u201318%), and 9% (95% CI, 8%\u201310%), respectively. Patients with acute myocardial infarction had similar device success (81% [95% CI, 74%\u201387%]), a 30\u2010day mortality rate of 20% (95% CI, 16%\u201325%), and intermediate\u2010term mortality rate of 14% (95% CI, 9%\u201319%). In non\u2013myocardial infarction populations, the 30\u2010day mortality rate was 13% (95% CI, 13%\u201314%), and the intermediate\u2010term mortality rate was 35% (95% CI, 34%\u201336%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with mitral regurgitation and cardiogenic shock, transcatheter edge\u2010to\u2010edge repair is associated with favorable 30\u2010day and intermediate\u2010term outcomes. Limitations, including the observational design of included studies and considerable heterogeneity, necessitate further research in this setting.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034932","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T03:33:51Z","timestamp":1741404831000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Transcatheter Edge\u2010to\u2010Edge Repair for Severe Mitral Regurgitation in Patients With Cardiogenic Shock: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8905","authenticated-orcid":false,"given":"Kyriakos","family":"Dimitriadis","sequence":"first","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Soulaidopoulos","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-9473","authenticated-orcid":false,"given":"Nikolaos","family":"Pyrpyris","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-1368","authenticated-orcid":false,"given":"\u039carios","family":"Sagris","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Aznaouridis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-3607","authenticated-orcid":false,"given":"Eirini","family":"Beneki","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-6306","authenticated-orcid":false,"given":"Panagiotis","family":"Theofilis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-7430","authenticated-orcid":false,"given":"Panagiotis","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Tatakis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-9950","authenticated-orcid":false,"given":"Christos","family":"Fragkoulis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"Shuvy","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Centre, Shaare Zedek Medical Center and Faculty of Medicine Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6340-3996","authenticated-orcid":false,"given":"Christina","family":"Chrysohoou","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Aggeli","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-6725","authenticated-orcid":false,"given":"Konstantinos","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, Hippokration General Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000923"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00846-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1759"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482941003802148"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.09.015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.04.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-015-0134-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208410"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_3_2_14_2","unstructured":"Cochrane Training . Chapter\u00a03: defining the criteria for including studies and how they will be grouped for the synthesis. https:\/\/training.cochrane.org\/handbook\/current\/chapter\u201003."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033502"},{"key":"e_1_3_2_16_2","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G","year":"2013","unstructured":"Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses. Ottawa Hospital Research Institute. 2013. https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019882"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2022.07.003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/19.00453"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29683"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28089"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.02.072"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12179"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29084"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195617"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.04.035"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2013.08.1450","article-title":"TCT\u2010699 MitraClip therapy in idiopathic vs ischemic dilated cardiomyopathy, a single center experience","volume":"62","author":"Buzzatti N","year":"2013","unstructured":"Buzzatti N, Taramasso M, Cioni M, Denti P, Colombo A, La Canna G, Alfieri O, Maisano F. TCT\u2010699 MitraClip therapy in idiopathic vs ischemic dilated cardiomyopathy, a single center experience. J Am Coll Cardiol. 2013;62:B213.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.10.025"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2019.1618514"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29552"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjacc\/zuaa031"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.04.052"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.042"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1565"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00653"},{"key":"e_1_3_2_37_2","first-page":"69","article-title":"Percutaneous edge\u2010to\u2010edge repair of mitral regurgitation as a bail\u2010out strategy in critically ill patients","volume":"25","author":"Pleger ST","year":"2013","unstructured":"Pleger ST, Chorianopoulos E, Krumsdorf U, Katus HA, Bekeredjian R. Percutaneous edge\u2010to\u2010edge repair of mitral regurgitation as a bail\u2010out strategy in critically ill patients. J Invasive Cardiol. 2013;25:69\u201372.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008435"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.597"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245849"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.08.037"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","unstructured":"Otto CM Nishimura RA Bonow RO Carabello BA Erwin JP Gentile F Jneid H Krieger EV Mack M McLeod C et\u00a0al. ACC\/AHA guideline for the Management of Patients with Valvular Heart Disease: executive summary: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines. Circulation. 2021:143;5:e35\u2013e71. doi: 10.1161\/CIR.0000000000000932","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23271"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2021.11.023"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab496"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-1-18"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00879-2"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/19.00336"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960240308"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90592-4"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-311037"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad387"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.02.033"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.002"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.09.020"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2918"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.08.008"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.034932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T03:33:58Z","timestamp":1741404838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.034932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":57,"alternative-id":["10.1161\/JAHA.124.034932"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.034932","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"2024-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e034932"}}