{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:57:38Z","timestamp":1787684258786,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:sec id=\"jah39774-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is a scarcity of data on the prevalence and clinical impact of cerebrovascular disease detected on preprocedural computed tomography (CT) before aortic valve replacement (AVR) in patients with severe aortic stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah39774-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among patients with severe aortic stenosis undergoing AVR, the authors compared clinical outcomes between patients with and without cerebrovascular disease detected on preprocedural CT, which was defined as chronic brain infarction or hemorrhage. The primary outcome measure in this study was a composite of all\u2010cause death or stroke. Among 567 study patients, 200 patients (35.3%) had cerebrovascular disease on preprocedural CT. Among 200 patients with cerebrovascular disease on preprocedural CT, only 28.5% of patients had a clinical history of symptomatic stroke. The cumulative 3\u2010year incidence of death or stroke was higher in patients with cerebrovascular disease on preprocedural CT than in those without cerebrovascular disease on preprocedural CT (40.7% versus 24.1%, log\u2010rank\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). After adjusting for confounders, the higher risk of patients with cerebrovascular disease on preprocedural CT relative to those without remained significant for death or stroke (hazard ratio [HR], 1.42 [95% CI, 1.02\u20131.98];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.04). Among 200 patients with cerebrovascular disease on preprocedural CT, patients with prior symptomatic stroke compared with those without were not associated with higher adjusted risk for death or stroke (HR, 1.18 [95% CI, 0.72\u20131.94];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.52).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah39774-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with severe aortic stenosis undergoing AVR, a substantial proportion had cerebrovascular disease on preprocedural CT, with a clinical history of symptomatic stroke in one\u2010fourth of patients. Regardless of history of symptomatic stroke, patients with cerebrovascular disease on preprocedural CT had worse clinical outcomes compared with those without cerebrovascular disease on preprocedural CT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035078","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:55:31Z","timestamp":1720526131000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebrovascular Disease Detected on Preprocedural Computed Tomography in Patients With Severe Aortic Stenosis Undergoing Aortic Valve Replacement"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-9617","authenticated-orcid":false,"given":"Ko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ueda","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiji","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-0351","authenticated-orcid":false,"given":"Yasuaki","family":"Takeji","sequence":"additional","affiliation":[{"name":"Kanazawa University Graduate School of Medical Sciences","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-3432","authenticated-orcid":false,"given":"Tomohiko","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-739X","authenticated-orcid":false,"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Hyogo College of Medicine","place":["Nishinomiya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tabata","sequence":"additional","affiliation":[{"name":"Kagoshima University","place":["Kagoshima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-5525","authenticated-orcid":false,"given":"Kenichi","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7604-1849","authenticated-orcid":false,"given":"Toru","family":"Morofuji","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-0578","authenticated-orcid":false,"given":"Akihiro","family":"Isotani","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-8205","authenticated-orcid":false,"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-2019","authenticated-orcid":false,"given":"Nobuhisa","family":"Ohno","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6304-7717","authenticated-orcid":false,"given":"Shinichi","family":"Kakumoto","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-4248","authenticated-orcid":false,"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-9762","authenticated-orcid":false,"given":"Kenji","family":"Minatoya","sequence":"additional","affiliation":[{"name":"Kyoto University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-4076","authenticated-orcid":false,"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Hirakata Kohsai Hospital","place":["Hirakata, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000923"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0135"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.12.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000116"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030686"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2016.05.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.11.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007546"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.06.049"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-1062"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022066"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70170-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03563"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0247"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz275"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-023-00942-x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204961"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa799"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.035078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:50:09Z","timestamp":1747302609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.035078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":20,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7,16]]}},"alternative-id":["10.1161\/JAHA.124.035078"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.035078","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"2024-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e035078"}}