{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:08Z","timestamp":1790716988317,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The congenital heart disease (CHD) population is growing and aging. We aim to examine the impact by describing the temporal trend and causes of lifetime hospitalization burden among the CHD population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From the Danish National Patient Registry, 23\u2009141 patients with CHD and their hospitalizations from 1977 to 2018 were identified, excluding patients with extracardiac malformation. Patients with CHD were categorized into major CHD and minor CHD, and each patient was matched with 10 controls by sex and year of birth. The rate of all\u2010cause hospitalization increased over time from 28.3 to 36.4 hospitalizations per 100 person\u2010years (PY) with rate difference (RD) per decade of 2.5 (95% CI, 2.0\u20133.1) hospitalizations per 100 PY for the patients with CHD, compared with the increase from 10.8 to 17.0 per 100 PY (RD per decade, 2.0 [95% CI, 1.8\u20132.2] per 100 PY) for the control group (RD for CHD versus control,\n              <jats:italic>P<\/jats:italic>\n              =0.08). The all\u2010cause hospitalization rate remained constant for the major CHDs (RD per decade, \u22120.2 [95% CI, \u22121.2 to 0.9] per 100 PY) but increased for the minor CHDs (RD per decade, 5.2 [95% CI, 4.3\u20136.0] per 100 PY). For all patients with CHD, the cardiovascular hospitalization rate remained constant over time (RD per decade, 0.2 [95% CI, \u22120.3 to 0.6] per 100 PY) whereas the noncardiovascular hospitalization rate increased (RD per decade, 2.1 [95% CI, 1.6\u20132.7] per 100 PY). The length of all\u2010cause hospital stays for all patients with CHD decreased from 2.7 (95% CI, 2.6\u20132.8) days per PY in 1977 to 1987 to 1.6 (95% CI, 1.6\u20131.7) days per PY in 2008 to 2018.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Compared with previous decades, patients with CHD have an increasing hospitalization rate, similar to the general population, but a decreasing length of hospital stay. The increase in hospitalization rate was driven by noncardiovascular hospitalizations, with the patients with minor CHD being the key contributor to the increasing rate.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035115","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:58:39Z","timestamp":1726052319000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal Trend in Hospitalization Among Patients With Congenital Heart Disease: A\u00a0Danish Nationwide Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7470-3326","authenticated-orcid":false,"given":"Chee Woon","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-6416","authenticated-orcid":false,"given":"Annette Schophuus","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5419-4736","authenticated-orcid":false,"given":"Camilla Margit","family":"Marstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-6049","authenticated-orcid":false,"given":"Pernille Steen","family":"B\u00e6kke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen 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