{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:22:48Z","timestamp":1784967768691,"version":"3.55.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Short sleep duration has been associated with an increased risk of cognitive impairment and dementia. Short sleep is associated with elevated blood pressure, yet the combined insult of short sleep and hypertension on brain health remains unclear. We assessed whether the association of sleep duration with cognition and vascular brain injury was moderated by hypertensive status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 682 dementia\u2010free participants (mean age, 62\u00b19\u2009years; 53% women) from the Framingham Heart Study completed assessments of cognition, office blood pressure, and self\u2010reported habitual and polysomnography\u2010derived sleep duration; 637 underwent brain magnetic resonance imaging. Linear regressions were performed to assess effect modification by hypertensive status on total sleep time (coded in hours) and cognitive and magnetic resonance imaging outcomes. There was a significant interaction between sleep duration and hypertensive status when predicting executive function\/processing speed (Trail Making B\u2010A) and white matter hyperintensities. When results were stratified by hypertensive status, longer sleep duration was associated with better executive functioning\/processing speed scores in the hypertensive group (meaning that shorter sleep duration was associated with poorer executive function\/processing speed scores) (self\u2010report sleep: \u03b2=0.041 [95% CI, 0.012\u20130.069],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.005; polysomnography sleep: \u03b2=0.045 [95% CI, 0.002\u20130.087],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.038), but no association was observed for the normotensive group. Similarly, shorter subjective sleep duration was associated with higher white matter hyperintensity burden in the hypertensive group (\u03b2=\u22120.115 [95% CI, \u22120.227 to \u22120.004],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.042), but not in the normotensive group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In individuals with hypertension, shorter sleep duration was associated with worse cognitive performance and greater brain injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035132","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:04:03Z","timestamp":1729839843000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Short Sleep Duration and Hypertension: A Double Hit for the Brain"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-6372","authenticated-orcid":false,"given":"Stephanie","family":"Yiallourou","sequence":"first","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andree\u2010Ann","family":"Baril","sequence":"additional","affiliation":[{"name":"Framingham Heart Study","place":["Framingham, USA"]},{"name":"H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al, CIUSSS\u2010NIM, Montreal, QC, Canada, Department of Medicine, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montr\u00e9al, Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Wiedner","sequence":"additional","affiliation":[{"name":"University of Texas Health San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Song","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Bernal","sequence":"additional","affiliation":[{"name":"University of Texas Health San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0852-2917","authenticated-orcid":false,"given":"Dibya","family":"Himali","sequence":"additional","affiliation":[{"name":"Framingham Heart Study","place":["Framingham, USA"]},{"name":"Boston University Chobanian & Avedisian School of Medicine","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-2267","authenticated-orcid":false,"given":"Marina G.","family":"Cavuoto","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University","place":["Clayton, Australia"]},{"name":"National Aging Research Institute (NARI)","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-2693","authenticated-orcid":false,"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"University of California","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-7778","authenticated-orcid":false,"given":"Alexa","family":"Beiser","sequence":"additional","affiliation":[{"name":"Framingham Heart Study","place":["Framingham, USA"]},{"name":"Boston University Chobanian & Avedisian School of Medicine","place":["Boston, USA"]},{"name":"Boston University School of Public Health","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-2622","authenticated-orcid":false,"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Framingham Heart Study","place":["Framingham, USA"]},{"name":"University of Texas Health San Antonio","place":["San Antonio, USA"]},{"name":"Boston University Chobanian & Avedisian School of Medicine","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-9481","authenticated-orcid":false,"given":"Jayandra J.","family":"Himali","sequence":"additional","affiliation":[{"name":"Framingham Heart Study","place":["Framingham, USA"]},{"name":"University of Texas Health San Antonio","place":["San Antonio, USA"]},{"name":"University of Texas Health Science Center","place":["San Antonio, USA"]},{"name":"Boston University Chobanian & Avedisian School of Medicine","place":["Boston, USA"]},{"name":"Boston University School of Public Health","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-8485","authenticated-orcid":false,"given":"Matthew P.","family":"Pase","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University","place":["Clayton, Australia"]},{"name":"Framingham Heart Study","place":["Framingham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Centers for Disease Control and Prevention . Short sleep duration among us adults. https:\/\/www.cdc.gov\/sleep\/data_statistics.html. 2017:2022."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2876"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003732"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22354-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac307"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab146"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000053"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530230032026"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1646"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.978114"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06019-8"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx179"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005947"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.11.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00709-y"},{"key":"e_1_3_2_18_2","first-page":"1077","article-title":"The Sleep Heart Health Study: design, rationale, and methods","volume":"20","author":"Quan SF","year":"1997","unstructured":"Quan SF, Howard BV, Iber C, Kiley JP, Nieto FJ, O'Connor GT, Rapoport DM, Redline S, Robbins J, Samet JM, et\u00a0al. The Sleep Heart Health Study: design, rationale, and methods. Sleep. 1997;20:1077\u20131085.","journal-title":"Sleep"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/21.7.759"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/03610730490484380"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012608"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.05.004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20546"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53817-8.00002-5"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011377"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.02.003"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3832"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000201850.52707.80"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9366-6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2305"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2834"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.4.405"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.06.021"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15716"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03123-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00255"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004373"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.270.1.R41"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.10.006"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227b227"},{"issue":"834","key":"e_1_3_2_44_2","first-page":"e816","article-title":"White matter lesions and brain gray matter volume in cognitively normal elders","volume":"33","author":"Raji CA","year":"2012","unstructured":"Raji CA, Lopez OL, Kuller LH, Carmichael OT, Longstreth WT Jr, Gach HM, Boardman J, Bernick CB, Thompson PM, Becker JT. White matter lesions and brain gray matter volume in cognitively normal elders. Neurobiol Aging. 2012;33(834):e816\u2013e837.","journal-title":"Neurobiol Aging"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.05.005"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313260"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.007"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1065245"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001284"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2021.1903302"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.879764"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1974-18.2019"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa112"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.124008"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.217"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.035132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:04:20Z","timestamp":1784113460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.035132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":55,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,11,5]]}},"alternative-id":["10.1161\/JAHA.124.035132"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.035132","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e035132"}}