{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:19:50Z","timestamp":1793582390439,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The effect of angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers (ACEI\/ARBs) on major adverse cardiovascular events (MACE) in patients who undergo coronary artery bypass graft surgery is equivocal. This retrospective, population\u2010based cohort study evaluated effect of exposure to an ACEI\/ARB on MACE using linked administrative databases that included all cardiac revascularization procedures, hospitalizations, and prescriptions for the population of British Columbia, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      All adults who underwent coronary artery bypass graft surgery between 2002 and 2020 were eligible. The primary outcome was time to MACE, defined as a composite of all\u2010cause death, myocardial infarction, and ischemic stroke using Cox proportional hazards models with inverse probability treatment weighting. Included were 15\u2009439 patients and 6191 (40%) were prescribed an ACEI\/ARB. Mean age was 66\u2009years, 83% were men, and 16% had heart failure (HF). Median exposure time was 40\u2009months. Over the 5\u2010year follow\u2010up, 1623 MACE occurred. Impact of exposure was different for patients with and without HF (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001 for interaction). After probability\u2010weighting and adjustment for relevant covariates, exposure to ACEI\/ARBs was associated with a lower hazard of MACE in patients with HF at 1\u2009year (hazard ratio, 0.13 [95% CI, 0.09\u20130.19]) and 5\u2009years (hazard ratio, 0.36 [95% CI, 0.30\u20130.44]). In patients without HF, ACEI\/ARBs had a lower hazard of MACE at 1\u2009year (hazard ratio, 0.35 [95% CI, 0.27\u20130.46]) and 5\u2009years (hazard ratio, 0.66 [95% CI, 0.58\u20130.76]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this population\u2010based study, ACEI\/ARBs were associated with a lower hazard of MACE in a cohort of patients post\u2013coronary artery bypass graft surgery irrespective of HF status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035215","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:47:10Z","timestamp":1717663630000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Angiotensin\u2010Converting Enzyme Inhibitors and Angiotensin Receptor Blockers After Coronary Artery Bypass Graft Surgery: A Population\u2010Based Cohort Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-898X","authenticated-orcid":false,"given":"Arden R.","family":"Barry","sequence":"first","affiliation":[{"name":"The University of British Columbia","place":["Vancouver, Canada"]},{"name":"Lower Mainland Pharmacy Services","place":["Surrey, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Helisaz","sequence":"additional","affiliation":[{"name":"GranTAZ Consulting","place":["Vancouver, Canada"]},{"name":"The University of British Columbia","place":["Vancouver, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-3086","authenticated-orcid":false,"given":"Abdollah","family":"Safari","sequence":"additional","affiliation":[{"name":"GranTAZ Consulting","place":["Vancouver, Canada"]},{"name":"University of Tehran","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-6438","authenticated-orcid":false,"given":"Peter","family":"Loewen","sequence":"additional","affiliation":[{"name":"The University of British Columbia","place":["Vancouver, Canada"]},{"name":"The University of British Columbia","place":["Vancouver, Canada"]},{"name":"The University of British Columbia","place":["Vancouver, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_3_2_3_2","unstructured":"Government of Canada . Heart Disease in Canada. 2024 https:\/\/www.canada.ca\/en\/public\u2010health\/services\/publications\/diseases\u2010conditions\/heart\u2010disease\u2010canada.html."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000182"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000134"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742cf6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281718"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu213"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.073"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01428-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685073"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2019.09.001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1380"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3532"},{"key":"e_1_3_2_18_2","unstructured":"Cardiac Services BC . Evaluation & Surveillance. 2024 http:\/\/www.cardiacbc.ca\/our\u2010services\/evaluation\u2010surveillance."},{"key":"e_1_3_2_19_2","unstructured":"Population Data BC . Services for Researchers. 2024 https:\/\/www.popdata.bc.ca\/researchers."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01440-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2012.01440.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135834"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000174293.17959.a1"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5083"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.4.455"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31817924d2"},{"key":"e_1_3_2_27_2","first-page":"457","article-title":"Measuring concurrent adherence to multiple related medications","volume":"15","author":"Choudhry NK","year":"2009","unstructured":"Choudhry NK, Shrank WH, Levin RL, Lee JL, Jan SA, Brookhart MA, Solomon DH. Measuring concurrent adherence to multiple related medications. Am J Manag Care. 2009;15:457\u2013464.","journal-title":"Am J Manag Care"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15391"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/18.1.41"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010713"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14284-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00634-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005408"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14385"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.07.004"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.035215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:56:05Z","timestamp":1790312165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.035215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6,18]]}},"alternative-id":["10.1161\/JAHA.124.035215"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.035215","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2024-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e035215"}}