{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:01:26Z","timestamp":1791309686575,"version":"4.3.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade\u2010long trend analysis, using data from a comprehensive, national, multicenter registry. We also seek to identify areas in need of improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This analysis involved patients with ischemic stroke or transient ischemic attack registered prospectively in the CRCS\u2010K\u2010NIH (Clinical Research Center for Stroke in Korea\u2013National Institute of Health) registry between 2011 and 2020. We examined temporal trends in risk factors, pathogenetic subtypes, acute management strategies, and outcomes for up to 1\u2009year following a stroke. Generalized linear mixed models were used to account for center clustering. The average age of 77\u2009662 patients increased 2.2\u2009years in men and 2.4\u2009years in women over the 10\u2010year follow\u2010up. Notably, in\u2010hospital neurological deterioration, 3\u2010month and 1\u2010year mortality rate, and cumulative incidence of recurrent stroke within 1\u2010year decreased over time after adjustments for age, sex, and initial stroke severity (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). However, functional outcomes at 3 months and 1 year remained unchanged. Endovascular thrombectomy increased from 5.4% in 2011 to 10.6% in 2020. Use of anticoagulants for atrial fibrillation, dual antiplatelet therapy, statins, and stroke unit care also increased. Contrarily, the rate of intravenous thrombolysis showed a slight decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study points to a reduction in death and risk of recurrent stroke over the past decade, paralleling enhancement in acute and preventive stroke management. Nevertheless, the decline in the use of intravenous thrombolysis and the lack of improvement in functional outcomes following stroke are concerning trends that warrant thorough investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035218","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:39:22Z","timestamp":1739947162000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-1663","authenticated-orcid":false,"given":"Tai Hwan","family":"Park","sequence":"first","affiliation":[{"name":"Seoul Medical Center","place":["Seoul, 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