{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:36:27Z","timestamp":1790602587827,"version":"4.1.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiovascular diseases (CVDs) are a leading global health concern. Emerging evidence suggests a potential protective role of well\u2010being in reducing CVD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a cohort analysis using the UK Biobank data set, encompassing 121\u2009317 participants. We assessed the well\u2010being of participants using a well\u2010being index derived from baseline questionnaires. Well\u2010being categories were derived by latent class analysis using general happiness and satisfaction with family, friendships, health, and finance situations. The relationship between well\u2010being and 4 major CVDs was analyzed using Cox proportional hazards models and Mendelian randomization. The study also examined the impacts of well\u2010being on lifestyle factors and inflammatory markers, and its mediating role in the well\u2010being\u2013CVD relationship. Higher well\u2010being was associated with a significantly reduced risk of various CVDs. Latent class analysis identified 4 distinct well\u2010being groups (low, variable, moderate\u2010to\u2010high, and high satisfaction), with higher satisfaction levels generally associated with lower risk of CVDs. Mendelian randomization suggested potential causal relationships between well\u2010being and reduced risk of CVDs. Participants with greater well\u2010being demonstrated healthier behaviors and lower levels of inflammatory markers. Mediation analysis indicated that lifestyle and inflammatory markers partially mediated the relationship between well\u2010being and CVDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study demonstrates a robust inverse association between well\u2010being and the risks of CVDs, suggesting that enhancing well\u2010being may be a viable strategy for CVD prevention. The role of lifestyle factors and inflammation as a mediator provides insight into possible biological pathways linking psychological states and cardiovascular health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035225","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T05:20:56Z","timestamp":1726636856000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Well\u2010Being and Cardiovascular Health: Insights From the UK Biobank Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-1683","authenticated-orcid":false,"given":"Jinghui","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-6987","authenticated-orcid":false,"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0526-9218","authenticated-orcid":false,"given":"Yiran","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-7450","authenticated-orcid":false,"given":"Yingjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-7331","authenticated-orcid":false,"given":"Ruidong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9632","authenticated-orcid":false,"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"},{"name":"Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-2085","authenticated-orcid":false,"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_2_3_2","volume-title":"The Atlas of Heart Disease and Stroke","author":"Organization WH","year":"2004","unstructured":"Organization WH . 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