{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:44:53Z","timestamp":1787867093144,"version":"build-2784847793"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">There is currently limited evidence comparing the association between metabolic dysfunction\u2013associated fatty liver disease (MAFLD), nonalcoholic fatty liver disease (NAFLD), and the risk of peripheral artery disease (PAD). This study aims to analyze the associations of MAFLD and NAFLD with incident PAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Two longitudinal studies, the UKB (UK Biobank) study (n=372\u2009216) and the ARIC (Atherosclerosis Risk in Communities) study (n=4681), categorized participants into MAFLD\/non\u2010MAFLD groups and NAFLD\/non\u2010NAFLD groups. Subsequently, participants were classified into 4 groups: non\u2013fatty liver disease, MAFLD\u2010only, NAFLD\u2010only, and both MAFLD and NAFLD groups. Cox proportional hazard model estimated associations of MAFLD\/NAFLD status, subtypes, and liver fibrosis severity with PAD risk. The MAFLD group had a higher risk of incident PAD compared with the non\u2010MAFLD group, and similarly, the NAFLD group had a higher risk compared with the non\u2010NAFLD group. Among these 4 groups, the MAFLD\u2010only group had the strongest association with the risk of incident PAD, while the NAFLD\u2010only group was not independently associated. Diabetic MAFLD subtype was significantly associated with increased PAD risk, and higher level of liver fibrosis scores correlated with elevated PAD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Both MAFLD and NAFLD are significantly associated with an increased incidence of PAD, with stronger associations in MAFLD and diabetic MAFLD population. These findings emphasize that the need for screening and prevention strategies for PAD in this high\u2010risk population is warranted. The assessment of MAFLD and its subtypes should be considered as an integral component of cardiovascular risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035265","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T23:10:25Z","timestamp":1731712225000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Associations of Metabolic Dysfunction\u2013Associated Fatty Liver Disease With Peripheral Artery Disease: Prospective Analysis in the UK Biobank and ARIC Study"],"prefix":"10.1161","volume":"13","author":[{"given":"YueRuiJing","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinQi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-7486","authenticated-orcid":false,"given":"ZongKai","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoYu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunFei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanChen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-2441","authenticated-orcid":false,"given":"ZhiYuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Harvard T. 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