{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:51:29Z","timestamp":1792151489065,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although myocardial infarction with nonobstructive coronary arteries (MINOCA) is more common in women, it is unknown whether sex is a risk factor for adverse outcomes in patients with MINOCA. We aimed to investigate the relationship between sex differences and outcomes of patients with MINOCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A systematic literature search was performed in PubMed, Embase, and Cochrane databases from their inception until August 2023 for relevant studies. End points were pooled using the Hartung\u2013Knapp\u2013Sidik\u2013Jonkman random\u2010effects model as odds ratio (OR) with 95% CIs. Nine studies, involving 30\u2009281 patients with MINOCA (comprising 18\u2009079 women and 12\u2009202 men), were included in the study. Women were older and had a higher prevalence of hypertension, diabetes, and stroke compared with men. The median duration of follow\u2010up was 3.5\u2009years, with an interquartile range of 2.2 to 4.2\u2009years. Pooled analysis revealed no statistically significant difference in the risk of all\u2010cause mortality (OR, 1.03 [95% CI, 0.87\u20131.22]), major adverse cardiovascular events (OR, 1.18 [95% CI, 0.89\u20131.58]), heart failure (OR, 1.32 [95% CI, 0.57\u20133.03]), stroke (OR, 1.13 [95% CI, 0.56\u20132.26]), and myocardial infarction (OR, 1.04 [95% CI, 0.29\u20133.76]) between the 2 groups. Regarding short\u2010term outcomes, women had a significantly higher risk of in\u2010hospital major adverse cardiovascular events compared with men (OR, 1.33 [95% CI, 1.16\u20131.53]) whereas there was no significant difference in the risk of in\u2010hospital mortality (OR, 0.90 [95% CI, 0.64\u20131.28]) between the 2 patient groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite the differences in demographics and comorbidity profiles, there was no significant difference in the long\u2010term outcomes for patients with MINOCA between sexes. However, it is noteworthy that women experienced a higher risk of in\u2010hospital major adverse cardiovascular events compared with men.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035329","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:19:42Z","timestamp":1722424782000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Sex Differences and Clinical Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: A Meta\u2010Analysis"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-9880","authenticated-orcid":false,"given":"Song P.","family":"Ang","sequence":"first","affiliation":[{"name":"Rutgers Health\/Community Medical Center","place":["Toms River"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia E.","family":"Chia","sequence":"additional","affiliation":[{"name":"Texas Tech 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