{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:10Z","timestamp":1787018110450,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias. We aimed to investigate whether catestatin, an endogenous catecholamine\u2010inhibiting peptide, ameliorates myocardial ischemia\u2010induced ventricular arrhythmias in rats and the underlying ionic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Adult male Sprague\u2010Dawley rats were randomly divided into control and catestatin groups. Ventricular arrhythmias were induced by ligation of the left anterior descending coronary artery and electrical stimulation. Action potential, transient outward potassium current, delayed rectifier potassium current, inward rectifying potassium current, and L\u2010type calcium current (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      ) of rat ventricular myocytes were recorded using a patch\u2010clamp technique. Catestatin notably reduced ventricular arrhythmia caused by myocardial ischemia\/reperfusion and electrical stimulation of rats. In ventricular myocytes, catestatin markedly shortened the action potential duration of ventricular myocytes, which was counteracted by potassium channel antagonists TEACl and 4\u2010AP, and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      current channel agonist Bay K8644. In addition, catestatin significantly increased transient outward potassium current, delayed rectifier potassium current, and inward rectifying potassium current density in a concentration\u2010dependent manner. Catestatin accelerated the activation and decelerated the inactivation of the transient outward potassium current channel. Furthermore, catestatin decreased\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      current density in a concentration\u2010dependent manner. Catestatin also accelerated the inactivation of the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      channel and slowed down the recovery of\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      from inactivation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Catestatin enhances the activity of transient outward potassium current, delayed rectifier potassium current, and inward rectifying potassium current, while suppressing the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>Ca\u2010L<\/jats:sub>\n                      in ventricular myocytes, leading to shortened action potential duration and ultimately reducing the ventricular arrhythmia in rats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035415","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:44:58Z","timestamp":1724064298000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of\n                    <i>I<\/i>\n                    <sub>to<\/sub>\n                    ,\n                    <i>I<\/i>\n                    <sub>K,<\/sub>\n                    and\n                    <i>I<\/i>\n                    <sub>K1<\/sub>\n                    and Inhibition of\n                    <i>I<\/i>\n                    <sub>Ca<\/sub>\n                    <sub>\u2010L<\/sub>\n                    in Rat Ventricular Myocytes"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-9682","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology Hebei Medical University Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-266X","authenticated-orcid":false,"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Care Unit Hebei General Hospital Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hebei General Hospital Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4417-7809","authenticated-orcid":false,"given":"Hui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Physiology Hebei Medical University Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-5195","authenticated-orcid":false,"given":"Hongyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology Hebei Medical University Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3189-0275","authenticated-orcid":false,"given":"Zishuo","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Physiology Hebei Medical University Shijiazhuang Hebei 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