{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:01:27Z","timestamp":1790312487830,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The incidental finding of a pericardial effusion (PE) poses a challenge in clinical care. PE is associated with malignant conditions or severe cardiac disease but may also be observed in healthy individuals. This study explored the prevalence, determinants, course, and prognostic relevance of PE in a population\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The STAAB (Characteristics and Course of Heart Failure Stages A\/B and Determinants of Progression) cohort study recruited a representative sample of the population of W\u00fcrzburg, aged 30 to 79\u2009years. Participants underwent quality\u2010controlled transthoracic echocardiography including the dedicated evaluation of the pericardial space. Of 4965 individuals included at baseline (mean age, 55\u00b112\u2009years; 52% women), 134 (2.7%) exhibited an incidentally diagnosed PE (median diameter, 2.7\u2009mm; quartiles, 2.0\u20134.1\u2009mm). In multivariable logistic regression, lower body mass index and higher NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) levels were associated with PE at baseline, whereas inflammation, malignancy, and rheumatoid disease were not. Among the 3901 participants attending the follow\u2010up examination after a median time of 34 (30\u201341) months, PE was found in 60 individuals (1.5%; n=18 new PE, n=42 persistent PE). Within the follow\u2010up period, 37 participants died and 93 participants reported a newly diagnosed malignancy. The presence of PE did not predict all\u2010cause death or the development of new malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Incidental PE was detected in about 3% of individuals, with the vast majority measuring &lt;10\u2009mm and completely resolving. PE was not associated with inflammation markers, death, incident heart failure, or malignancy. Our findings corroborate the view of current guidelines that a small PE in asymptomatic individuals can be considered an innocent phenomenon and does not require extensive short\u2010term monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035549","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T22:50:48Z","timestamp":1718491848000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Utility of Pericardial Effusion in the General Population: Findings From the STAAB Cohort Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-9354","authenticated-orcid":false,"given":"Floran","family":"Sahiti","sequence":"first","affiliation":[{"name":"University Hospital and University of Wurzburg","place":["Germany"]},{"name":"University Hospital of 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