{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:15:15Z","timestamp":1787678115259,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Brain injury is one of the most serious complications after cardiac arrest (CA). To prevent this phenomenon, rapid cooling with total liquid ventilation (TLV) has been proposed in small animal models of CA (rabbits and piglets). Here, we aimed to determine whether hypothermic TLV can also offer neuroprotection and mitigate cerebral inflammatory response in large animals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Anesthetized pigs were subjected to 14\u2009minutes of ventricular fibrillation followed by cardiopulmonary resuscitation. After return of spontaneous circulation, animals were randomly subjected to normothermia (control group, n=8) or ultrafast cooling with TLV (TLV group, n=8). In the latter group, TLV was initiated within a window of 15\u2009minutes after return of spontaneous circulation and allowed to reduce tympanic, esophageal, and bladder temperature to the 32 to 34 \u00b0C range within 30\u2009minutes. After 45\u2009minutes of TLV, gas ventilation was resumed, and hypothermia was maintained externally until 3\u2009hours after CA, before rewarming using heat pads (0.5 \u00b0C\u20131 \u00b0C\/h). After an additional period of progressive rewarming for 3\u2009hours, animals were euthanized for brain withdrawal and histological analysis. At the end of the follow\u2010up (ie, 6\u2009hours after CA), histology showed reduced brain injury as witnessed by the reduced number of Fluroro\u2010Jade C\u2010positive cerebral degenerating neurons in TLV versus control. IL (interleukin)\u20101ra and IL\u20108 levels were also significantly reduced in the cerebrospinal fluid in TLV versus control along with cerebral infiltration by CD3+ cells. Conversely, circulating levels of cytokines were not different among groups, suggesting a discrepancy between local and systemic inflammatory levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Ultrafast cooling with TLV mitigates neuroinflammation and attenuates acute brain lesions in the early phase following resuscitation in large animals subjected to CA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035617","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T14:45:41Z","timestamp":1724078741000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrafast Cooling With Total Liquid Ventilation Mitigates Early Inflammatory Response and Offers Neuroprotection in a\u00a0Porcine Model of Cardiac Arrest"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-6705","authenticated-orcid":false,"given":"Yara","family":"Abi Zeid Daou","sequence":"first","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB Cr\u00e9teil France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, IMRB, AfterROSC Network Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB Cr\u00e9teil France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, IMRB, AfterROSC Network Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lidouren","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB Cr\u00e9teil France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, IMRB, AfterROSC Network 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