{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:49:31Z","timestamp":1790120971486,"version":"4.0.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Intracranial atherosclerotic stenosis is a leading cause of ischemic stroke and recurrent events due to plaque instability. High\u2010resolution magnetic resonance imaging identifies plaque enhancement as a key marker of instability. This study evaluated the efficacy of combined high\u2010intensity statins and proprotein convertase subtilisin\/kexin type 9 inhibitors in plaque stabilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this prospective, single\u2010arm study, patients with acute stroke and intracranial atherosclerotic stroke in the M1 segment of the middle cerebral artery or basilar artery were enrolled. After 24\u2009weeks of intensive statin and evolocumab therapy, high\u2010resolution magnetic resonance imaging assessments of intracranial vessels were conducted at baseline and follow\u2010up. The primary end point was the change in stenosis degree; secondary end points included changes in plaque enhancement (contrast ratio) and plaque burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Thirty\u2010six patients (median age, 58\u2009years) participated. After therapy, stenosis decreased from 75.9% (interquartile range, 69.5%\u201384.8%) to 65.3% (interquartile range, 53.8%\u201375.0%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Contrast ratio grades and contrast volume decreased significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and lumen area increased (from 1.03\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 0.59\u20131.72\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ] to 2.08\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 1.00\u20133.10\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). No significant changes were observed in wall area, wall area index, or remodeling index. A notable correlation between the decrease in low\u2010density lipoprotein cholesterol\/apolipoprotein B ratio and reduction in contrast volume was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Combining proprotein convertase subtilisin\/kexin type 9 inhibitors with high\u2010intensity statins may improve plaque stability and reduce lumen stenosis in patients with intracranial atherosclerotic stenosis. Larger randomized controlled trials are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      ; Unique identifier: ChiCTR2200058029.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.035651","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T05:21:31Z","timestamp":1737091291000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Intensive Statins and Proprotein Convertase Subtilisin\/Kexin Type 9 Inhibitors on Intracranial Artery Plaque Stability: A Prospective Single\u2010Arm Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-9213","authenticated-orcid":false,"given":"Weiqi","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-5793","authenticated-orcid":false,"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahua","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-6062","authenticated-orcid":false,"given":"Changzheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-0566","authenticated-orcid":false,"given":"Xihai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering Tsinghua University School of Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-6647","authenticated-orcid":false,"given":"Xinyi","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-9606","authenticated-orcid":false,"given":"Bernard","family":"Yan","sequence":"additional","affiliation":[{"name":"Neurointervention Service, Department of Radiology Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-612X","authenticated-orcid":false,"given":"Zefeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First People\u2019s Hospital of Foshan Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00376-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.041"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221100032"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.577973"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020941"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.029"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16951"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000178543.19433.20"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62038-3"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.05.010"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122812"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-320893"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh299"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv161"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.3780"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019140"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000419"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.05.008"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01869-1"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032596"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061302"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956078"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27561"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106857"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4998"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21532"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00706-7"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.10.007"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08893-2"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043826"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00184"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac361"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037184"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.795666"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027759"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32290-0"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.035651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:04:10Z","timestamp":1737529450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.035651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,21]]}},"alternative-id":["10.1161\/JAHA.124.035651"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.035651","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"2024-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e035651"}}