{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:39:13Z","timestamp":1792247953100,"version":"4.4.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it remains largely unexplored whether the different WMH distribution patterns associated with CAA (posterior confluent and subcortical multispot) reflect alternative pathophysiological mechanisms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a combined in\u00a0vivo MRI\u2014ex vivo MRI\u2014neuropathological study in patients with definite CAA. Formalin\u2010fixed hemispheres from 19 patients with CAA, most of whom also had in\u00a0vivo MRI available, underwent 3T MRI, followed by standard neuropathological examination of the hemispheres and targeted neuropathological assessment of WMH patterns. Ex\u00a0vivo WMH volume was independently associated with CAA severity (\n              <jats:italic>P<\/jats:italic>\n              =0.046) but not with arteriolosclerosis (\n              <jats:italic>P<\/jats:italic>\n              =0.743). In targeted neuropathological examination, compared with normal\u2010appearing white matter, posterior confluent WMHs were associated with activated microglia (\n              <jats:italic>P<\/jats:italic>\n              =0.043) and clasmatodendrosis (\n              <jats:italic>P<\/jats:italic>\n              =0.031), a form of astrocytic injury. Trends were found for an association with white matter rarefaction (\n              <jats:italic>P<\/jats:italic>\n              =0.074) and arteriolosclerosis (\n              <jats:italic>P<\/jats:italic>\n              =0.094). An exploratory descriptive analysis suggested that the histopathological correlates of WMH multispots were similar to those underlying posterior confluent WMHs.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study confirmed that vascular amyloid \u03b2 severity in the cortex is significantly associated with WMH volume in patients with definite CAA. The histopathological substrates of both posterior confluent and WMH multispots were comparable, suggesting overlapping pathophysiological mechanisms, although these exploratory observations require confirmation in larger studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035744","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:53:02Z","timestamp":1731322382000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-743X","authenticated-orcid":false,"given":"Nazanin","family":"Makkinejad","sequence":"first","affiliation":[{"name":"J. 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Philip Kistler Stroke Research Center, Department of Neurology Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-4504","authenticated-orcid":false,"given":"Corinne A.","family":"Auger","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8595-1922","authenticated-orcid":false,"given":"Kali A.","family":"vom Eigen","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eugenio","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital, Harvard Medical School Charlestown MA USA"},{"name":"Computer Science and Artificial Intelligence Laboratory, MIT Cambridge MA USA"},{"name":"Centre for Medical Image Computing University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-8887","authenticated-orcid":false,"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Stroke Research Center, Department of Neurology Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-5237","authenticated-orcid":false,"given":"Valentina","family":"Perosa","sequence":"additional","affiliation":[{"name":"J. 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