{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:46:08Z","timestamp":1792842368735,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent Mendelian randomization and meta\u2010analysis highlight the relevance of MCP\u20101 (monocyte chemoattractant protein\u20101) in stroke. We aimed to investigate the associations between MCP\u20101 and clinical outcomes in patients with ischemic stroke or transient ischemic attack and test whether inflammation mediates or jointly contributes to the relationships.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 10\u2009700 patients from the Third China National Stroke Registry study were included. Multivariable Cox regression was used for recurrent stroke and all\u2010cause death, and logistic regression was used for poor functional outcome. Mediation analyses were performed to clarify whether inflammation mediates the associations. After adjusting for potential confounders, low MCP\u20101 level (&lt;337.6\u2009pg\/mL) was associated with a reduced risk of all\u2010cause death (hazard ratio [HR], 0.65 [95% CI, 0.51\u20130.82]) and poor functional outcome (odds ratio, 0.81 [95% CI, 0.70\u20130.94]) but was not associated with recurrent stroke (HR, 1.10 [95% CI, 0.95\u20131.27]), compared with high MCP\u20101 level (\u2265337.6\u2009pg\/mL). The association between MCP\u20101 and all\u2010cause death was partially mediated by highly sensitive C\u2010reactive protein, interleukin\u20106, and YKL\u201040 (Chitinase\u20103\u2010like protein 1; mediated proportion: 7.4%, 10.5%, and 7.4%, respectively). The corresponding mediated proportion for poor functional outcome was 9.9%, 17.1%, and 7.1%, respectively. Patients with combined high levels of MCP\u20101 and inflammatory biomarkers had the highest risks of all\u2010cause death and poor functional outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Low plasma MCP\u20101 level was associated with decreased risks of all\u2010cause mortality and poor functional outcome after ischemic stroke or transient ischemic attack. Inflammation partially mediated and jointly contributed to the associations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035820","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:35:08Z","timestamp":1723203308000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Monocyte Chemoattractant Protein\u20101, Inflammatory Biomarkers, and Prognosis of Patients With Ischemic Stroke or Transient Ischemic Attack: Fndings From a Nationwide Registry Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-709X","authenticated-orcid":false,"given":"Qin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Department of Clinical Epidemiology 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