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However, the extent to which PWD has subclinical influences on overall aging patterns of the brain is not clearly understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Here, using neuroimaging and ECG data from the UK Biobank, we use a novel regional \u201cbrain age\u201d method to identify the brain aging networks associated with abnormal PWD. We find associations between short PWD and accelerated brain aging in the sensorimotor, frontoparietal, ventral attention, and dorsal attention networks, even in the absence of overt cardiac diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These findings contribute to our understanding of the relationship between PWD and structural brain aging. This work emphasizes the need for continued study designs that consider brain\u2010based outcomes related to abnormally short PWD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.035881","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:35:10Z","timestamp":1732275310000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["P\u2010Wave Duration Is Associated With Aging Patterns in Structural Brain Networks"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-9085","authenticated-orcid":false,"given":"Elizabeth","family":"Haddad","sequence":"first","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Imaging Genetics Center University of Southern California Marina Del Rey CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Matloff","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-6639","authenticated-orcid":false,"given":"Gilsoon","family":"Park","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-9006","authenticated-orcid":false,"given":"Mengting","family":"Liu","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-8950","authenticated-orcid":false,"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Imaging Genetics Center University of Southern California Marina Del Rey CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1088\/0143-0815\/10\/3\/001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172399499"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313563"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.06.014"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.831734"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.223"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.52928"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045866"},{"key":"e_1_3_1_10_2","first-page":"750","article-title":"Vascular cognitive impairment and dementia","volume":"28","author":"Chang Wong E","year":"2022","unstructured":"Chang Wong E, Chang CH. 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