{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:21:20Z","timestamp":1787829680095,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertension is a global health issue causing increased cardiovascular morbidity and mortality. Adherence to prescribed medication is a crucial factor in obtaining targeted outcomes, and fixed\u2010dose combined antihypertensive pills (FCAPs) have been shown to help combat difficulties associated with polypharmacy management. This study investigated the influence of combination antihypertensives on blood pressure (BP) management.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data from the 2013 to 2020 NHANES (National Health and Nutrition Examination Survey) were analyzed. Participants were included if between 18 and 79\u2009years of age and were prescribed 2 antihypertensive classes. BP was deemed controlled if &lt;140\/&lt;90\u2009mm\u2009Hg. Examiner documentation and questionnaire data determined prescription antihypertensive medication usage and the presence of an FCAP. Descriptive statistics and multivariate regression analyses were used to compare the 2 groups. Subgroup analysis was performed for stricter BP goals of &lt;130\/&lt;80\u2009mm\u2009Hg. A total of 15\u2009927\u2009747 weighted participants met the inclusion criteria, 32.7% of whom were undergoing management with an FCAP. Participants with an FCAP were 1.78 (95% CI, 1.28\u20132.47,\n              <jats:italic>P<\/jats:italic>\n              =0.001) times more likely to have controlled BP (76.4% versus 67.3%) than those without an FCAP. Subgroup analysis revealed that FCAPs were associated with stricter BP goals (odds ratio [OR], 1.65,\n              <jats:italic>P<\/jats:italic>\n              =0.008; 87.6% versus 71.2%) compared with those without.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Participants with an FCAP were more likely to exhibit controlled BP, including participants with clinical atherosclerotic cardiovascular disease and those targeting stricter control. Clinicians can immediately and meaningfully affect their patient's BP by opting for FCAPs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036046","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:35:54Z","timestamp":1732764954000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Combination Antihypertensive Pills on Blood Pressure Control"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-3823","authenticated-orcid":false,"given":"Joseph","family":"Heaton","sequence":"first","affiliation":[{"name":"Department of Medicine Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0006-7304","authenticated-orcid":false,"given":"Anmol","family":"Johal","sequence":"additional","affiliation":[{"name":"Department of Medicine Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-3498","authenticated-orcid":false,"given":"Abbas","family":"Alshami","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Okoh","sequence":"additional","affiliation":[{"name":"Division of Cardiology Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndausung","family":"Udongwo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Morehouse School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Schoenfeld","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Saybolt","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-7183","authenticated-orcid":false,"given":"Jesus","family":"Almendral","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-8302","authenticated-orcid":false,"given":"Brett","family":"Sealove","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jersey Shore University Medical Center Neptune City NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111437"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27377-2"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032582"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313220"},{"key":"e_1_3_1_7_2","first-page":"1","article-title":"Hypertension prevalence and control among adults: United States, 2015\u20132016","volume":"2017","author":"Fryar CD","year":"2017","unstructured":"Fryar CD, Ostchega Y, Hales CM, Zhang G, Kruszon\u2010Moran D. Hypertension prevalence and control among adults: United States, 2015\u20132016. 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National Health and Nutrition Examination Survey, 2017\u2013March 2020 prepandemic file: sample design, estimation, and analytic guidelines. Vital Health Stat. 2022;1:1\u201336.","journal-title":"Vital Health Stat"},{"key":"e_1_3_1_22_2","volume-title":"Hypertension Cascade: Hypertension Prevalence, Treatment and Control Estimates Among US Adults Aged 18\u2009Years and Older Applying the Criteria From the American College of Cardiology and American Heart Association's 2017 Hypertension Guideline\u2014NHANES 2017\u20132020","author":"Centers for Disease Control and Prevention","year":"2023","unstructured":"Centers for Disease Control and Prevention . Hypertension Cascade: Hypertension Prevalence, Treatment and Control Estimates Among US Adults Aged 18\u2009Years and Older Applying the Criteria From the American College of Cardiology and American Heart Association's 2017 Hypertension Guideline\u2014NHANES 2017\u20132020. Atlanta: Centers for Disease Control and Prevention; 2023. 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