{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:02:32Z","timestamp":1789783352830,"version":"4.0.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Proteinuria is a risk factor for cardiovascular events, but its prognostic value for sudden cardiac arrest (SCA) in young individuals remains unproven. We aimed to evaluate whether proteinuria in young people is associated with an increased risk of SCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Individuals aged between 20 and 39\u2009years who underwent health screening between 2009 and 2012 in South Korea were included (n=6\u2009891\u2009400). Urine protein was measured using the spot urine dipstick method. Main outcome was SCA identified by\n              <jats:italic>International Classification of Diseases, Tenth Revision (ICD\u201010).<\/jats:italic>\n              Participants included in the analysis were followed\u2010up till December 2020, and Cox proportional hazards model was used to demonstrate the risk of SCA. The mean age was 30.9\u00b15.0\u2009years, and 3\u2009775\u2009535 (59.5%) were men. The mean follow\u2010up duration was 9.4\u00b11.2\u2009years. During follow\u2010up, SCA occurred in 5352 individuals (0.08%). Participants with proteinuria had a higher incidence of SCA (n=182, incidence rate 0.19, during 962\u2009956 person\u2010year follow\u2010up) than those without proteinuria (n=5170, incidence rate 0.09, during 58\u2009465\u2009181 person\u2010year follow\u2010up). Adjustment of confounders resulted higher risk of SCA in participants with proteinuria (adjusted hazard ratio 1.71 [95% CI=1.47\u20131.99],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Participants with proteinuria +3\u20134 showed a significant increase in the risk of SCA (2.94 [1.96\u20134.40],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The influence of proteinuria on SCA was stronger in advanced chronic kidney disease (stage 3 and stage 4\u20135).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Proteinuria was significantly associated with an increased risk of SCA in young people. Individuals with pre\u2010existing chronic kidney disease showed a stronger association between proteinuria and the risk of SCA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036077","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:30:19Z","timestamp":1741861819000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Proteinuria Is Associated With an Increased Risk of Sudden Cardiac Arrest in the Young Population"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-0197","authenticated-orcid":false,"given":"Joo Hee","family":"Jeong","sequence":"first","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Gi","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Soongsil University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-9079","authenticated-orcid":false,"given":"Seung\u2010Young","family":"Roh","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine, and Korea University Guro Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-8003","authenticated-orcid":false,"given":"Hyoung Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-6636","authenticated-orcid":false,"given":"Yun Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-1522","authenticated-orcid":false,"given":"Jaemin","family":"Shim","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-647X","authenticated-orcid":false,"given":"Young\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-508X","authenticated-orcid":false,"given":"Jong\u2010Il","family":"Choi","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine and Korea University Anam Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007453"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510687"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.006970"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010330"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac141"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510687"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad313"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071781"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01764-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031045"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16543-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/Circulationaha.117.031262"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010030250"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005685"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv319"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.23838\/pfm.2021.00135"},{"key":"e_1_3_2_18_2","first-page":"1333","article-title":"Proteinuria in adults: a diagnostic approach","volume":"62","author":"Carroll MF","year":"2000","unstructured":"Carroll MF, Temte JL. 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