{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:34:50Z","timestamp":1791862490193,"version":"4.3.4"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stroke is a pressing public health issue worldwide. This study aimed to forecast the future temporal trends and distribution characteristics of the global stroke burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Global data on stroke incidence, prevalence, deaths, and disability\u2010adjusted life years between 1990 and 2021 were obtained from the GBD (Global Burden of Disease) Study 2021. The temporal trends of stroke burden were estimated using various regression models. Gross domestic product per capita was adopted as a predictor in the model to consider the impact of economic development on stroke burden. Projections of stroke burden up to 2050 were generated using the optimal model selected based on the Akaike information criterion, encompassing global, World Bank income levels, national levels, and sex\u2010age groups. In 2050, we projected 21.43\u2009million stroke cases, 159.31\u2009million survivors, 12.05\u2009million deaths, and 224.86\u2009million disability\u2010adjusted life years due to stroke globally. From 2021 to 2050, there was a declining trend in the global age\u2010adjusted stroke rates, with \u22127% in incidence, \u22124% in prevalence, \u221228% in deaths, and \u221228% in disability\u2010adjusted life years. Upper\u2010middle\u2010income countries were projected to have the most severe stroke burden, followed by lower\u2010middle\u2010income countries, low\u2010income countries, and high\u2010income countries. The stroke burden in over half of the 204 countries and territories was expected to be alleviated from 2022 to 2050. Men and older women worldwide bear higher burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stroke remains a serious global health challenge, especially in low\u2010income and middle\u2010income countries. Targeted implementation of prevention and interventions is imperative across diverse demographic groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036142","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T06:38:07Z","timestamp":1732257487000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Projections of the Stroke Burden at the Global, Regional, and National Levels up to 2050 Based on the Global Burden of Disease Study 2021"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5560-8296","authenticated-orcid":false,"given":"Yiran","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Psychology, School of Mental Health and Psychological Sciences Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Intelligent Medical Engineering, School of Biomedical Engineering Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9780-5901","authenticated-orcid":false,"given":"Hujuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Intelligent Medical Engineering, School of Biomedical Engineering Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Intelligent Medical Engineering, School of Biomedical Engineering Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9331-0283","authenticated-orcid":false,"given":"Baoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Intelligent Medical Engineering, School of Biomedical Engineering Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-2016","authenticated-orcid":false,"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Biomedical Imaging and Biomedical Informatics &amp; Data Science Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2627-1189","authenticated-orcid":false,"given":"Chuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital Beijing China"},{"name":"Peking University Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders Peking University Sixth Hospital Beijing China"},{"name":"NHC Key Laboratory of Mental Health Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-1676","authenticated-orcid":false,"given":"Yanzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Course and Population Health Sciences King\u2019s College London London United Kingdom"},{"name":"National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Xia","sequence":"additional","affiliation":[{"name":"Medical Image Center The Third Affiliated Hospital of Anhui Medical University\/ Hefei No1. 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