{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:20:20Z","timestamp":1793398820517,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Limited data exist on long\u2010term outcomes after transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). This meta\u2010analysis aims to elucidate outcome trends following TAVR versus SAVR in patients with severe aortic stenosis and low\u2010surgical risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A systematic search was conducted in PubMed, Embase, Scopus, and the Cochrane Library databases from inception until May 2024, to identify studies comparing TAVR versus SAVR in patients with low\u2010surgical risk (Society of Thoracic Surgeons predicted risk of mortality score &lt;4%). The primary outcome was all\u2010cause mortality. Secondary outcomes included cardiovascular mortality, stroke, disabling stroke, rehospitalization, myocardial infarction, aortic valve reintervention, permanent pacemaker implantation, and new\u2010onset atrial fibrillation. Binary random\u2010effects models were used to compare the risk of each outcome across various follow\u2010up intervals and the risk of bias was assessed using the Cochrane Collaboration's Risk of Bias\u20102 tool. The meta\u2010analysis included 6 randomized trials including 4682 patients. TAVR was associated with a lower risk of all\u2010cause mortality than SAVR in the 30\u2010day (hazard ratio [HR: 0.45] [95% CI: 0.26\u20130.77],\n                      <jats:italic toggle=\"no\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 0%) and 30\u2010day to 1\u2010year (HR: 0.55 [95% CI: 0.37\u20130.81],\n                      <jats:italic toggle=\"no\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 16%) follow\u2010ups. However, the risk of all\u2010cause mortality was similar during &gt;1\u2010year follow\u2010ups. TAVR was associated with a significantly lower risk of cardiovascular mortality, disabling stroke, rehospitalization, new\u2010onset atrial fibrillation, and a higher risk of permanent pacemaker implantation compared with SAVR during the 30\u2010day follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">TAVR was associated with a lower risk of all\u2010cause mortality within the first year of post\u2010procedural follow\u2010up compared with SAVR. However, the risk of all\u2010cause mortality was similar in &gt;1\u2010year follow\u2010ups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036179","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T21:35:07Z","timestamp":1729287307000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Trends in Transcatheter Versus Surgical Aortic Valve Replacement Outcomes in Patients With Low\u2010Surgical Risk: A Systematic Review and Meta\u2010Analysis of Randomized Trials"],"prefix":"10.1161","volume":"13","author":[{"given":"Sina","family":"Kazemian","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences","place":["Tehran, 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