{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:07:58Z","timestamp":1790845678928,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used data from the MIDA\u2010Q (Mitral Regurgitation International DAtabase\u2010Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to January 2020 from 5 tertiary centers across North America, Europe, and the Middle East. A cohort of 2917 (mean age: 66\u2009years, 70.8% male patients, follow\u2010up: 5.2 [3.3\u20138.3] years) consecutive patients with severe DMR was included and long\u2010term mortality was analyzed. RVD, identified in 426 (14.6%) patients, was associated with reduced 8\u2010year survival (55%\u00b13% versus 77%\u00b11%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), overall and in all subgroups of patients, even after comprehensive adjustment including left ventricular dilatation and dysfunction, DMR severity, pulmonary pressures, and surgery (adjusted hazard ratio, 1.44 [95% CI, 1.17\u20131.77];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). This excess mortality was observed under medical management (adjusted hazard ratio, 1.57 [95% CI, 1.20\u20132.05];\n              <jats:italic>P<\/jats:italic>\n              =0.001) and after surgical correction of mitral regurgitation (adjusted hazard ratio, 1.45 [95% CI, 1.02\u20132.05];\n              <jats:italic>P<\/jats:italic>\n              =0.039). Patients with RVD undergoing surgery within 3 months of diagnosis experienced a better 8\u2010year survival (73%\u00b14% versus 43%\u00b14%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), even after adjustment (adjusted hazard ratio, 0.44 [95% CI, 0.29\u20130.67];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) despite an increase of 1\u2010month postoperative mortality (7.1% versus 0.5% for patients without RVD;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">RVD is observed in 14.6% of severe DMR and exhibits a powerful and independent association with excess mortality partially attenuated by mitral surgery. Therefore, assessment of right ventricular systolic function should be included in routine DMR evaluation and in the clinical decision\u2010making process.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036206","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T10:10:30Z","timestamp":1734516630000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-9848","authenticated-orcid":false,"given":"Yohann","family":"Bohbot","sequence":"first","affiliation":[{"name":"Department of Cardiology Amiens University Hospital Amiens France"},{"name":"UR UPJV 7517 Jules Verne University of Picardie Amiens 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-9054","authenticated-orcid":false,"given":"Thierry","family":"Le Tourneau","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-8242","authenticated-orcid":false,"given":"Yan","family":"Topilsky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Medical Center and Sackler Faculty of Medicine Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemence","family":"Antoine","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rusinaru","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amiens University 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