{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:45:08Z","timestamp":1790181908158,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Unknown cardioembolic sources are frequent causes of cryptogenic stroke. We analyzed the risk of atrial fibrillation (AF) or high burden of ectopic atrial activity (HBEA) in patients with cryptogenic stroke, assessing atrial function and 1\u2010year outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The ARIES (Atrial Imaging and Cardiac Rhythm in Cryptogenic Embolic Stroke) study is an observational study including patients with cryptogenic stroke. We analyzed the frequency of AF and HBEA (&gt;3000 atrial ectopic beats\/day or &gt;2 bursts or atrial tachycardia between 3 beats and \u226430\u2009seconds) in two 30\u2010day Holter\u2010ECGs, comparing advanced echocardiography signs of left atrial (LA) dysfunction according to rhythm: AF, HBEA, and normal sinus rhythm. We also evaluated 1\u2010year stroke recurrence and mortality. The study included 109 patients; 35 (32.1%) patients had AF, 27 (24.8%) HBEA, and 47 (43.1%) normal sinus rhythm. Compared with those with normal sinus rhythm, patients with AF presented higher 2\u2010dimensional and 3\u2010dimensional LA indexed volumes (38.8\u00b111.2 versus 27.3\u00b111.8\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and 50.6\u00b117.2 versus 34.0\u00b115.4\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      , respectively,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), lower 3\u2010dimensional LA ejection fraction (50\u00b114.6 versus 62.7\u00b111.8,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), LA reservoir strain (22.0\u00b18.6 versus 30.4\u00b110.5,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), and LA contraction strain (10.5\u00b18.18 versus 17.1\u00b17.5,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), remaining significant in multivariate analysis. Patients with HBEA showed higher LA indexed volumes and lower LA reservoir strain than patients with normal sinus rhythm only in univariate analysis. There were no differences in ischemic recurrence or mortality among the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with cryptogenic stroke showed a high incidence of AF and HBEA. AF is strongly related to LA volume, LA function, and LA reservoir and contraction strain, whereas HBEA showed milder structural changes. Advanced LA echocardiography could help patient selection for long\u2010term ECG monitoring in suspected cardiac sources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036236","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T06:32:27Z","timestamp":1724913147000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Atrial Imaging and Cardiac Rhythm in Cryptogenic Embolic Stroke: The ARIES Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-3581","authenticated-orcid":false,"given":"Ricardo","family":"Rigual","sequence":"first","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-2004","authenticated-orcid":false,"given":"Sergio","family":"Castrej\u00f3n\u2010Castrej\u00f3n","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-4668","authenticated-orcid":false,"given":"Luc\u00eda","family":"Fern\u00e1ndez\u2010Gass\u00f3","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-4775","authenticated-orcid":false,"given":"Jes\u00fas","family":"Garc\u00eda\u2010Castro","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-1287","authenticated-orcid":false,"given":"Jorge","family":"Rodr\u00edguez\u2010Pardo","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-9413","authenticated-orcid":false,"given":"Marcel","family":"Mart\u00ednez\u2010Cossiani","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-9422","authenticated-orcid":false,"given":"Elena","family":"de Celis\u2010Ruiz","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-6980","authenticated-orcid":false,"given":"Laura","family":"Casado\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-444X","authenticated-orcid":false,"given":"Carlos","family":"Herv\u00e1s","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-2916","authenticated-orcid":false,"given":"Elisa","family":"Alonso\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-6580","authenticated-orcid":false,"given":"Mar\u00eda","family":"Alonso de Leci\u00f1ana","sequence":"additional","affiliation":[{"name":"La Paz University Hospital. La Paz University Hospital Research Institute (IdiPAZ). 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