{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:27:41Z","timestamp":1782408461528,"version":"3.54.5"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,20]]},"abstract":"<jats:sec id=\"jah310683-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Percutaneous left ventricular assist devices are used prophylactically to prevent hypotension during high\u2010risk percutaneous coronary intervention. However, the impact of preprocedural hemodynamic profiles on procedural and clinical outcomes in these patients is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310683-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients from the central venous access device PROTECT III registry (NCT04136392) were categorized according to preprocedural mean blood pressure (MBP). Procedural and in\u2010hospital outcomes, including hypotensive episodes, need for prolonged percutaneous left ventricular assist device support, and in\u2010hospital death, were compared between groups. We also assessed the relationship between preprocedural MBP and 90\u2010day major adverse cardiovascular and cerebrovascular events, which included all\u2010cause death, myocardial infarction, stroke\/transient ischemic attack, and repeat revascularization, as well as with 1\u2010year mortality. A total of 1159 patients underwent percutaneous left ventricular assist device\u2010supported high\u2010risk percutaneous coronary intervention and were stratified into 4 hemodynamic profiles of preprocedural MBP level: MBP&gt;100\u2009mm\u2009Hg (n=242), &gt;90 to \u2264100\u2009mm\u2009Hg (n=264), &gt;80 to \u226490\u2009mm\u2009Hg (n=306), and \u226480\u2009mm\u2009Hg (n=347). Lower preprocedural MBP was associated with baseline anemia, history of heart failure, left main disease, and transfer from another hospital. In\u2010hospital and procedural adverse outcomes did not differ between the BP categories. However, 90\u2010day major adverse cardiovascular and cerebrovascular events rates and 1\u2010year mortality increased with decreasing baseline BP levels. The association between BP category and 1\u2010year mortality remained significant after adjustment for other factors (hazard ratio [HR], 0.79 [95% CI, 0.71\u20130.88],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310683-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In a real\u2010world cohort undergoing high\u2010risk percutaneous coronary intervention with percutaneous left ventricular assist device support, there was no association between hemodynamic status and in\u2010hospital outcomes. Lower preprocedural BP was associated with higher rates of 90\u2010day major adverse cardiovascular and cerebrovascular events and 1\u2010year mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310683-sec-0005\" xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04136392.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036367","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:35:25Z","timestamp":1747301725000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device\u2010Supported High\u2010Risk Percutaneous Coronary Intervention: The PROTECT III Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Guillaume","family":"Bonnet","sequence":"first","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]},{"name":"Hopital Cardiologique Haut\u2010L\u00e9v\u00eaque, Bordeaux University Hospital","place":["Bordeaux, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8138","authenticated-orcid":false,"given":"Karl\u2010Philipp","family":"Rommel","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]},{"name":"Heart Center at University of Leipzig and Leipzig Heart Institute","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6709-0840","authenticated-orcid":false,"given":"Batla","family":"Falah","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-7497","authenticated-orcid":false,"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]},{"name":"London and Queen Mary University of London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-5891","authenticated-orcid":false,"given":"Yiran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-3332","authenticated-orcid":false,"given":"Michael J.","family":"Schonning","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-4451","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]},{"name":"Weill Cornell Medicine","place":["New York, USA"]},{"name":"Gothenburg University","place":["Gothenburg, Sweden"]},{"name":"Sahlgrenska University Hospital","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2466","authenticated-orcid":false,"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]},{"name":"St. Francis Hospital","place":["Roslyn, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-6753","authenticated-orcid":false,"given":"M. Babar","family":"Basir","sequence":"additional","affiliation":[{"name":"Henry Ford Health System","place":["Detroit, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5896-728X","authenticated-orcid":false,"given":"William W.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Henry Ford Health System","place":["Detroit, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2399-8320","authenticated-orcid":false,"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.03.020"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022061"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009960"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.09.039"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.098194"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058229"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044007"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00428"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.493"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.02.006"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.04.036"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.09.007"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.15-480"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.036367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T12:04:48Z","timestamp":1747742688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.036367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,20]]}},"alternative-id":["10.1161\/JAHA.124.036367"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.036367","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e036367"}}