{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:48:16Z","timestamp":1776822496288,"version":"3.51.2"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The purpose of this study was to describe the correlates and outcomes in adults with unrepaired partial anomalous pulmonary venous return and intact atrial septum (PAPVR\u2010IAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We identified adults with PAPVR\u2010IAS who received care at the Mayo Clinic, while those with unrepaired PAPVR\u2010IAS comprised the reference group. Clinical indices (New York Heart Association class, peak oxygen consumption, and NT\u2010proBNP [N\u2010terminal pro\u2010B\u2010type natriuretic peptide]) and echo\u2010derived right heart indices (right atrial [RA] volume, RA reservoir strain, right ventricular [RV] free wall strain, RV end\u2010diastolic area, and RV systolic pressure) were assessed at baseline and 3\u2010year and 5\u2010year follow\u2010up. There were 80 patients and 38 patients with unrepaired versus repaired PAPVR\u2010IAS, respectively. The clinical predictors of surgical repair were the number of anomalous veins, RA volume, and RV end\u2010diastolic area. The PAPVR\u2010IAS risk score, derived from these clinical predictors, was associated with surgical repair (adjusted odds ratio, 1.37 [95% CI, 1.24\u20131.65] per unit increase in risk score; area under the curve, 0.742). Among patients with unrepaired PAPVR\u2010IAS with 3\u2010year (n=73) and 5\u2010year follow\u2010up (n=36), there was no temporal change in clinical indices (New York Heart Association class, predicted peak oxygen consumption, and NT\u2010proBNP) and right heart indices (RA volume index, RA reservoir strain, RV end\u2010diastolic area index, RV free wall strain, and RV systolic pressure).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The PAPVR\u2010IAS risk score can be used to assess the odds of requiring surgical repair. Furthermore, there was no temporal deterioration in clinical and right heart indices during follow\u2010up in adults with unrepaired PAPVR\u2010IAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036403","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T07:04:38Z","timestamp":1724742278000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of Adults With Unrepaired Partial Anomalous Pulmonary Venous Return and Intact Atrial Septum"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-3631","authenticated-orcid":false,"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-3302","authenticated-orcid":false,"given":"Ahmed","family":"Younis","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-3174","authenticated-orcid":false,"given":"Ahmed E.","family":"Ali","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-5323","authenticated-orcid":false,"given":"Snigdha","family":"Karnakoti","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-6794","authenticated-orcid":false,"given":"Elizabeth H.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-1290","authenticated-orcid":false,"given":"Joseph A.","family":"Dearani","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-1181","authenticated-orcid":false,"given":"Christopher","family":"Francois","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-0344","authenticated-orcid":false,"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester","place":["Rochester, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0096-5588(20)31117-X"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.627224"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.012371"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000602"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa701"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.110"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.09.074"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.05.049"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.04.031"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014148"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01290.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12382"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200309000-00011"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1700882"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.08.076"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.015"}],"container-title":["Journal 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