{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:19:05Z","timestamp":1780759145076,"version":"3.54.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,20]]},"abstract":"\n Background<\/jats:title>\n Research studies of spontaneous coronary artery dissection (SCAD) have been primarily focused on European\u2010ancestry individuals, with limited recognition and investigation in non\u2013European\u2010ancestry individuals. While SCAD has not been well ascertained in non\u2013European\u2010ancestry groups, pleiotropic associated traits identified in those of European ancestry have been assessed in individuals of other ancestries. Whether these traits are associated with the complex genetic architecture of SCAD in those of non\u2010European ancestry has not been previously investigated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We investigated the associations of an established SCAD polygenic score with multiple vascular diseases in \u2248900\u2009000 ancestrally diverse participants of large\u2010scale studies. Individual\u2010level data from the UK Biobank and the Million Veteran Program and summary statistics of publicly available databases were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A set of associations between SCAD polygenic score and related vascular diseases were replicated in non\u2010European samples. Notable associations with the SCAD polygenic score included (1) coronary artery disease, myocardial infarction, and migraine headache in a Hispanic group (coronary artery disease: odds ratio [OR], 0.93 [95% CI, 0.90\u20130.95];\n P<\/jats:italic>\n =2.35\u00d710\n \u22127<\/jats:sup>\n ; myocardial infarction: OR, 0.88 [95% CI, 0.80\u20130.96];\n P<\/jats:italic>\n =5.73\u00d710\n \u22123<\/jats:sup>\n ; migraine headache: OR, 1.03 [95% CI, 1.01\u20131.06];\n P<\/jats:italic>\n =1.86\u00d710\n \u22122<\/jats:sup>\n ) of the Million Veteran Program; (2) headache in an African\u2010ancestry group (OR, 1.22 [95% CI, 1.06\u20131.41];\n P<\/jats:italic>\n =6.94\u00d710\n \u22123<\/jats:sup>\n ) and a South Asian\u2013ancestry group (OR, 1.18 [95% CI, 1.02\u20131.37];\n P<\/jats:italic>\n =2.43\u00d710\n \u22122<\/jats:sup>\n ) of the UK Biobank; and (3) coronary artery disease, myocardial infarction, and migraine headache in East Asian\u2013ancestry cohorts (coronary artery disease: OR, 0.95 [95% CI, 0.93\u20130.98];\n P<\/jats:italic>\n =2.66\u00d710\n \u22123<\/jats:sup>\n ; myocardial infarction: OR, 0.86 [95% CI, 0.83\u20130.89];\n P<\/jats:italic>\n =9.51\u00d710\n \u221216<\/jats:sup>\n ; migraine headache: OR, 1.27 [95% CI, 1.10\u20131.47];\n P<\/jats:italic>\n =1.03\u00d710\n \u22123<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Pleiotropic associations of SCAD polygenic risk with related vascular diseases previously identified in European\u2010ancestry groups showed notable, largely consistent patterns in non\u2013European\u2010ancestry groups.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.036525","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T09:44:28Z","timestamp":1747129468000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cross\u2010Ancestry Associations of Spontaneous Coronary Artery Dissection Genetic Risk With Coronary Atherosclerosis and Migraine Headache"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-1604","authenticated-orcid":false,"given":"Chang","family":"Xu","sequence":"first","affiliation":[{"name":"University of Michigan School of Public Health","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-8320","authenticated-orcid":false,"given":"Min\u2010Lee","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School","place":["Ann Arbor, USA"]},{"name":"University of Michigan","place":["Ann Arbor, USA"]},{"name":"University of Michigan Medical School","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-6062","authenticated-orcid":false,"given":"Pik Fang","family":"Kho","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System","place":["Palo Alto, USA"]},{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-1172","authenticated-orcid":false,"given":"Shoa L","family":"Clarke","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System","place":["Palo Alto, USA"]},{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-4339","authenticated-orcid":false,"given":"Catherine","family":"Tcheandjieu","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System","place":["Palo Alto, USA"]},{"name":"Gladstone Institutes","place":["San Francisco, USA"]},{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8459","authenticated-orcid":false,"given":"Patricia A.","family":"Peyser","sequence":"additional","affiliation":[{"name":"University of Michigan School of Public Health","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-2276","authenticated-orcid":false,"given":"Cathy Shen\u2010Jang","family":"Fann","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih\u2010Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang Ming Chiao Tung University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"VA Million Veteran Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-984X","authenticated-orcid":false,"given":"Jacqueline","family":"Saw","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Vancouver, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-7599","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Michigan School of Public Health","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-0009","authenticated-orcid":false,"given":"Themistocles L.","family":"Assimes","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System","place":["Palo Alto, USA"]},{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-5249","authenticated-orcid":false,"given":"Santhi K.","family":"Ganesh","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School","place":["Ann Arbor, USA"]},{"name":"University of Michigan Medical School","place":["Ann Arbor, 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