{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:21:43Z","timestamp":1785280903789,"version":"3.55.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Systemic inflammatory response syndrome (SIRS) following cardiovascular interventions is associated with adverse events during hospitalization and follow\u2010up. Mitral transcatheter edge\u2010to\u2010edge repair is increasingly utilized for treatment of mitral regurgitation (MR). We investigated whether SIRS following mitral transcatheter edge\u2010to\u2010edge repair may occur and be associated with adverse clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 158 consecutive patients with severe MR undergoing mitral transcatheter edge\u2010to\u2010edge repair were studied. SIRS was defined by leukocytosis (\u226512\u2009\u00d7\u200910\n              <jats:sup>9<\/jats:sup>\n              \/L) and fever (\u226538 \u00b0C) within 48 hours after intervention. Baseline inflammation was measured by absolute neutrophil and lymphocyte counts and neutrophil\u2010lymphocyte ratio. The primary end point of major cardiovascular events was the composite of nonfatal myocardial infarction, nonfatal stroke, and all\u2010cause death. Recurrent MR at follow\u2010up was also recorded. The mean patient age was 80.8\u00b18.8\u2009years. Forty\u2010four (27.9%) developed SIRS. Neutrophil\u2010lymphocyte ratio correlated with onset of leukocytosis and fever (\n              <jats:italic>P<\/jats:italic>\n              =0.04). During a median follow\u2010up of 12.5 (5.4\u201317.4) months, the primary end point occurred in 27 (17.1%) patients (6 myocardial infarction, 5 strokes, and 16 deaths). Patients with SIRS more often had severe MR (79.5% versus 62.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.02) at follow\u2010up. After adjustment for pertinent variables, SIRS (HR 2.73 [95% CI, 1.08\u20136.86];\n              <jats:italic>P<\/jats:italic>\n              =0.03) was independently associated with major cardiovascular events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">SIRS after mitral transcatheter edge\u2010to\u2010edge repair is a strong independent predictor of major cardiovascular events. Closer follow\u2010up is warranted because patients with SIRS have more severe MR at follow\u2010up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036539","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:52:21Z","timestamp":1731322341000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Systemic Inflammatory Response Syndrome With Cardiovascular Events After Mitral Transcatheter Edge\u2010to\u2010Edge Repair"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-1869","authenticated-orcid":false,"given":"Carlo","family":"Mannina","sequence":"first","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai New York NY"},{"name":"Department of Internal Medicine University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-7155","authenticated-orcid":false,"given":"Akarsh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-7010","authenticated-orcid":false,"given":"Andreina","family":"Carbone","sequence":"additional","affiliation":[{"name":"Unit of Cardiology University Hospital \"Luigi Vanvitelli\" Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-9950","authenticated-orcid":false,"given":"Eduardo","family":"Bossone","sequence":"additional","affiliation":[{"name":"Department of Public Health Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-7318","authenticated-orcid":false,"given":"Antonino","family":"Tuttolomondo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-2668","authenticated-orcid":false,"given":"Edgar","family":"Argulian","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mount Sinai Morningside Icahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Neibart","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Fuster Hospital Icahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-7877","authenticated-orcid":false,"given":"Michael B.","family":"Hadley","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Fuster Hospital Icahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-5471","authenticated-orcid":false,"given":"Jonathan","family":"Halperin","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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