{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:31:11Z","timestamp":1774351871581,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Percutaneous coronary intervention (PCI) of the left main coronary artery (LMCA) for stable angina has steadily increased. Outcomes stratified by sex are inconclusive and limited. We assessed sex\u2010based trends and differences in clinical outcomes among patients with stable angina who received LMCA PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively collected data on patients with stable angina who underwent LMCA PCI (2006\u20132022) from the UK national PCI registry. The primary outcome of interest was inpatient mortality. Secondary outcomes were major bleeding and major cardiovascular and cerebral events. Multivariate logistic regression was used to assess adjusted odds ratio for outcome of interest. Of the 24\u2009271 LMCA PCI performed, 5497 (22.7%) were in women. Women were older than men (median 72.7 versus 70.4) and less likely to have their PCI via radial access (50.3% versus 58.9%). More women had PCI guided by intravascular ultrasound (43.4% versus 41.2%). Women had significantly lower comorbid burden than men. Higher prevalence of chronic renal failure (6.72% versus 4.77%), smoking history (61.47% versus 45.68%), diabetes (27.36% versus 25.74%), prior myocardial infarction (45.36% versus 35.89%), and prior coronary artery bypass grafting (42.13% versus 30.34%) was observed in men than in women, respectively;\n              <jats:italic>P<\/jats:italic>\n              value &lt;0.005 for all. Women had higher adjusted mortality (adjusted odds ratio, 1.63 [95% CI, 1.1\u20132.3]) and major bleeding events (adjusted odds ratio, 2.07 [95% CI, 1.19\u20133.59]). Although odds of major cardiovascular and cerebral events (adjusted odds ratio, 1.27[95% CI, 0.9\u20131.6]) were higher in women, it was not statistically significant.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite being less comorbid, women had a significant increase in their mortality and major bleeding events following LMCA PCI. A sex\u2010tailored approach considering age, intravascular imaging, and vascular access may improve outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036569","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T04:07:50Z","timestamp":1731730070000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sex Differences in Patients Undergoing Left Main Stem Percutaneous Coronary Intervention for Stable Angina: Data From a National Registry"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-6187","authenticated-orcid":false,"given":"Warkaa","family":"Shamkhani","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences Keele University Stoke\u2010on\u2010Trent United Kingdom"},{"name":"Department of Cardiology Royal Stoke University Hospital Stoke\u2010on\u2010Trent United Kingdom"},{"name":"Department of Cardiology Queen Elizabeth Hospital Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafraan","family":"Zathar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Queen Elizabeth Hospital Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-5433","authenticated-orcid":false,"given":"Sophia","family":"Khattak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Queen Elizabeth Hospital Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Nolan","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences Keele University Stoke\u2010on\u2010Trent United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-9112","authenticated-orcid":false,"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Interventional Cardiology Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-3534","authenticated-orcid":false,"given":"Tim","family":"Kinnaird","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences Keele University Stoke\u2010on\u2010Trent United Kingdom"},{"name":"Department of Cardiology University Hospital of Wales Cardiff United 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