{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:08:13Z","timestamp":1780488493521,"version":"3.54.1"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Admixture mapping can be leveraged to identify genomic loci associated with disease traits in admixed individuals\u00a0such as Hispanic Americans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We characterized fine\u2010scale population structure of participants (n=105\u2009108) in the multiethnic eMERGE\u2010III (electronic Medical Records and Genomics) cohort, using reference panels from the 1000 Genomes Project and a Native American cohort. We defined \u201cgenetically admixed Hispanic Americans\u201d as those having \u226510% Native American genetic ancestry (n=5025), in addition to European (specifically, Iberian) and African genetic ancestry. This population descriptor was subsequently applied to 3 other cohorts: the MESA (Multi\u2010Ethnic Study of Atherosclerosis; n=1176), WHI (Women\u2019s Health Initiative; n=2873), and the HCHS\/SOL (Hispanic Community Health Study\/Study of Latinos; n=7804). We inferred local ancestry along the genome in genetically admixed Hispanic Americans in each cohort using RFMix2 with phased haplotypes from SHAPEIT2. Local ancestry proportions were used for admixture mapping of lipid traits (low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, total cholesterol, and triglycerides) using extended linear mixed models that incorporated multiple or single ancestries. After accounting for fixed\u2010effect covariates and random effects, ancestry proportions at the following loci were associated with lipid traits in the HCHS\/SOL cohort: 11q12.2 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =6.8\u00d710\n                      <jats:sup>\u22127<\/jats:sup>\n                      ) with low\u2010density lipoprotein cholesterol, 2p23.3 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =5.2\u00d710\n                      <jats:sup>\u22127<\/jats:sup>\n                      ) with total cholesterol, and 11q23.3 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =7.3\u00d710\n                      <jats:sup>\u221212<\/jats:sup>\n                      ) with triglycerides. The LDL cholesterol and triglyceride loci replicated in at least one independent cohort, whereas the total cholesterol locus showed suggestive evidence for replication in the eMERGE cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.073). Native American (NAMR) ancestry appeared to drive the LDL\u2010C association, whereas both NAMR and Iberian population in Spain (IBS) ancestries contributed to the triglyceride signal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Admixture mapping in genetically admixed Hispanic Americans identified genomic loci influencing lipid traits and the different ancestral origins driving these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036650","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:43Z","timestamp":1762175743000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Admixture Mapping of Lipid Traits in Hispanic 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A.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center","place":["Seattle"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Stanaway","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center","place":["Seattle"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Weng","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-6433","authenticated-orcid":false,"given":"Daniel J.","family":"Schaid","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-3471","authenticated-orcid":false,"given":"Iftikhar 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