{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:49:15Z","timestamp":1753883355673,"version":"3.41.2"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study aimed at evaluating the association between plasma human cartilage glycoprotein\u201039 (YKL\u201040) and cognitive impairment at 3\u2009months among patients with acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Plasma YKL\u201040 levels were measured in 604 participants from the China Antihypertensive Trial in Acute Ischemic Stroke. Cognitive impairment outcomes were assessed at 3\u2009months poststroke using the Mini\u2010Mental State Examination and the Montreal Cognitive Assessment. According to the Mini\u2010Mental State Examination score, patients in the highest quartile of YKL\u201040 had a 2.01\u2010fold (95% CI, 1.23\u20133.29;\n              <jats:italic>P<\/jats:italic>\n              for trend=0.009) risk of poststroke cognitive impairment compared with those in the lowest quartile. Each 1 SD difference of logarithm\u2010transformed YKL\u201040 was associated with a 28% (95% CI, 7\u201353) increased risk for the outcome. The multiple\u2010adjusted spline regression model confirmed dose\u2013response relationships between YKL\u201040 and poststroke cognitive impairment (\n              <jats:italic>P<\/jats:italic>\n              for linearity=0.01). Adding YKL\u201040 to a model containing conventional risk factors significantly improved the discriminatory power (area under the receiver operating characteristic curve improved by 0.02,\n              <jats:italic>P<\/jats:italic>\n              =0.03). When cognitive impairment was defined using the Montreal Cognitive Assessment score, similar findings were observed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Elevated YKL\u201040 levels were associated with an increased risk of cognitive impairment at 3 months among patients with acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n              ; Unique Identifier: NCT01840072.\n            <\/jats:p>\n          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