{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:54Z","timestamp":1788876594522,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Clinical characteristics and outcomes of patients with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) are not fully understood, particularly in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We enrolled a total of 8881 patients with acute MI from the Miyagi Acute Myocardial Infarction Registry Study (2012\u20132020), with a median age of 69\u2009years. Among them, 239 patients (2.7%) were diagnosed with MINOCA. Compared with those with MI with obstructive coronary artery disease (MI\u2010CAD), patients with MINOCA were more often women, had a higher incidence of non\u2013ST\u2010segment\u2013elevation MI and a lower prevalence of dyslipidemia. Compared with patients with MI\u2010CAD, patients with MINOCA in all age groups (&lt;59, 60\u201369, 70\u201379, &gt;80\u2009years of age) had a higher incidence of non\u2013ST\u2010segment\u2013elevation MI. Additionally, those \u226459\u2009years of age were more often women and had a lower prevalence of diabetes and dyslipidemia. In\u2010hospital mortality increased with age in patients with MI\u2010CAD (3.9% for &lt;59\u2009years of age, 5.6% for 60\u201369\u2009years of age, 8.3% for 70\u201379\u2009years of age, and 15.2% for &gt;80\u2009years of age;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01), but not in patients with MINOCA (4.5%, 7.4%, 6.0%, and 9.6%, respectively;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.36). Compared with patients with MI\u2010CAD, patients with MINOCA had lower in\u2010hospital mortality for Killip class IV (40.7% versus 20.0%; adjusted odds ratio [OR], 0.31 [95% CI, 0.10\u20130.94];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04) and renal dysfunction (20.0% versus 7.1%; adjusted OR, 0.29 [95% CI, 0.09\u20130.96];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with MINOCA exhibit distinct clinical characteristics and outcomes compared with those with MI\u2010CAD, particularly in terms of age, sex, prevalence of comorbidities, and in\u2010hospital mortality. These findings underscore the importance of tailored clinical approaches for patients with MINOCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036802","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:34:42Z","timestamp":1739946882000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Outcome of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries in Japan: Insights From the Miyagi Acute Myocardial Infarction Registry Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-9284","authenticated-orcid":false,"given":"Kiyotaka","family":"Hao","sequence":"first","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-1087","authenticated-orcid":false,"given":"Jun","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]},{"name":"International University of Health and Welfare","place":["Narita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Fukui","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-9999","authenticated-orcid":false,"given":"Tomohiko","family":"Shindo","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-7312","authenticated-orcid":false,"given":"Kazuma","family":"Oyama","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Nishimiya","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4985-7828","authenticated-orcid":false,"given":"Shigeo","family":"Godo","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-9210","authenticated-orcid":false,"given":"Takashi","family":"Shiroto","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-4826","authenticated-orcid":false,"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]},{"name":"International University of Health and Welfare","place":["Narita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5236","authenticated-orcid":false,"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.08.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907223410402"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp328"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011201"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-22-0779"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003443"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009174"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz403"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.011990"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0799"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.10.006"},{"key":"e_1_3_2_14_2","unstructured":"United Nations Department of Economic and Social Affairs Population Division . 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