{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:09Z","timestamp":1787018109563,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Coronary artery disease is a leading cause of morbidity and mortality in the United States. Coronary artery disease can lead to major complications including myocardial infarction (MI). The association of dietary cholesterol with coronary artery disease remains inconsistent. We examined the relation of dietary cholesterol with the incidence of MI among participants of the Million Veteran Program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Million Veteran Program is a prospective cohort database collecting genetic and nongenetic factors influencing chronic diseases. We analyzed data from 180\u2009156 veterans with complete information on relevant dietary intake. The association between dietary cholesterol and MI risk was assessed using both linear and nonlinear models. Statistical significance was determined using the Wald test for linear trends and the likelihood ratio test for nonlinearity, alongside comparisons between high (\u2265300\u2009mg\/d) and low (&lt;300\u2009mg\/d) cholesterol intake groups. In this study of 180\u2009156 veterans with mean follow\u2010up of 3.5\u2009years, we observed a linear, dose\u2013response association between dietary cholesterol intake and risk of MI, with every 100\u2010mg\/d increment in cholesterol intake associated with a 5% higher MI risk (relative risk [RR], 1.05 [95% CI, 1.02\u20131.08]). Subjects consuming &gt;300\u2009mg\/d of cholesterol had a 15% increased MI risk compared with those consuming less (RR, 1.15 [95% CI, 1.06\u20131.25]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">We found that dietary cholesterol intake was linearly associated with greater risk of MI. These findings contribute to the growing literature highlighting the impact dietary cholesterol has on cardiovascular health. Reductions in cholesterol intake, which can be achieved by decreasing the intake of meat and eggs, may reduce the risk of incident MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036819","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:33:01Z","timestamp":1738992781000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary Cholesterol and Myocardial Infarction in the Million Veteran Program"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-3763","authenticated-orcid":false,"given":"Xuan\u2010Mai T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Million Veteran Program Boston Coordinating Center VA Boston Healthcare System Boston MA"},{"name":"Department of Medicine, David Geffen School of Medicine University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-2748","authenticated-orcid":false,"given":"Yanping","family":"Li","sequence":"additional","affiliation":[{"name":"Million Veteran Program Boston Coordinating Center VA Boston Healthcare System Boston MA"},{"name":"Department of Nutrition Harvard T. 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