{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:15:25Z","timestamp":1793330125008,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Balloon angioplasty with drug\u2010coated balloons (DCBs) is frequently used during percutaneous coronary intervention for in\u2010stent restenosis. Despite its frequent use, there is a lack of long\u2010term data on the efficacy of DCB angioplasty. We conducted an investigation on the long\u2010term efficacy outcome of in\u2010stent restenosis, comparing DCBs, drug\u2010eluting stents, and plain old balloon angioplasty.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted a nationwide analysis from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) including in\u2010stent restenosis lesions undergoing coronary angiography between June 11, 2013, and January 14, 2022. The primary outcome of this study was target\u2010lesion revascularization within a 5\u2010year follow\u2010up. Secondary outcomes included all\u2010cause death, cardiovascular death, myocardial infarction, and any percutaneous coronary intervention. The outcomes were analyzed using a multivariable Cox proportional hazard model or Poisson regression, as appropriate. A total of 10\u2009561 lesions from 9062 patients were included. Compared with plain old balloon angioplasty, the use of DCB angioplasty was associated with less target\u2010lesion revascularization (risk ratio, 0.69 [95% CI, 0.57\u20130.82]), all\u2010cause death (risk ratio, 0.72 [95% CI, 0.59\u20130.88]), and cardiovascular death (hazard ratio [HR], 0.59 [95% CI, 0.45\u20130.78]). No difference was observed for myocardial infarction or any percutaneous coronary intervention. Compared with drug\u2010eluting stents, the use of DCBs was associated with higher rates of target\u2010lesion revascularization (HR, 1.20 [95% CI, 1.06\u20131.37]). No difference was observed for all\u2010cause death, cardiovascular death, myocardial infarction, or any percutaneous coronary intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this long\u2010term nationwide analysis, the use of DCB angioplasty showed superior outcomes compared with plain old balloon angioplasty within 5\u2009years but higher rates of repeat revascularizations compared with drug\u2010eluting stents.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.036839","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:33:17Z","timestamp":1732275197000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Drug\u2010Coated Balloons Versus Drug\u2010Eluting Stents or Plain Old Balloon Angioplasty: A Long\u2010Term in\u2010Stent Restenosis Study"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8398-4221","authenticated-orcid":false,"given":"Sacharias","family":"von Koch","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8031-5998","authenticated-orcid":false,"given":"Mikael","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-1851","authenticated-orcid":false,"given":"Hans Christian","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-4014","authenticated-orcid":false,"given":"Sammy","family":"Zwackman","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences and Department of Cardiology Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-2924","authenticated-orcid":false,"given":"Juliane","family":"Jurga","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institute and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-715X","authenticated-orcid":false,"given":"Per","family":"Grimfj\u00e4rd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V\u00e4stmanlands Hospital V\u00e4ster\u00e5s Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-7927","authenticated-orcid":false,"given":"Matthias","family":"G\u00f6tberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-9801","authenticated-orcid":false,"given":"Moman A.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-5766","authenticated-orcid":false,"given":"David","family":"Erlinge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University, Sk\u00e5ne University Hospital Lund 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