{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:51:12Z","timestamp":1792615872610,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mosaic loss of chromosome Y (mLOY) in leukocytes of men reflects genomic instability from aging, smoking, and environmental exposures. A similar mosaic loss of chromosome X (mLOX) occurs among women. However, the associations between mLOY, mLOX, and risk of incident heart diseases are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We estimated associations between mLOY, mLOX, and risk of incident heart diseases requiring hospitalization, including atrial fibrillation, myocardial infarction, ischemic heart disease, cardiomyopathy, and heart failure. We analyzed 190\u2009613 men and 224\u2009853 women with genotyping data from the UK Biobank. Among these participants, there were 37\u2009037 men with mLOY and 13\u2009978 women with mLOX detected using the Mosaic Chromosomal Alterations caller. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs of each incident heart disease in relation to mLOY in men and mLOX in women. Additionally, Mendelian randomization was conducted to estimate causal associations. Among men, detectable mLOY was associated with elevated risk of atrial fibrillation (HR, 1.06 [95% CI, 1.03\u20131.11]). The associations were apparent in both never smokers (HR, 1.07 [95% CI, 1.01\u20131.14]) and ever smokers (HR, 1.05 [95% CI, 1.01\u20131.11]) as well as men aged &gt;60 and \u226460\u2009years. Mendelian randomization analyses supported causal associations between mLOY and atrial fibrillation (HR\n                      <jats:sub>MR\u2010PRESSO<\/jats:sub>\n                      , 1.15 [95% CI, 1.13\u20131.18]). Among postmenopausal women, we found a suggestive inverse association between detectable mLOX and atrial fibrillation risk (HR, 0.90 [95% CI, 0.83\u20130.98]). However, associations with mLOY and mLOX were not found for other heart diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our findings suggest that mLOY and mLOX reflect sex\u2010specific biological processes or exposure profiles related to incident atrial fibrillation requiring hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.036984","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T05:18:58Z","timestamp":1730956738000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Associations Between Mosaic Loss of Sex Chromosomes and Incident Hospitalization for Atrial Fibrillation in the United Kingdom"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-3131","authenticated-orcid":false,"given":"Jungeun","family":"Lim","sequence":"first","affiliation":[{"name":"Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4052-1110","authenticated-orcid":false,"given":"Aubrey K.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-2554","authenticated-orcid":false,"given":"Batel","family":"Blechter","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-4707","authenticated-orcid":false,"given":"Jianxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-3064","authenticated-orcid":false,"given":"Weiyin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"},{"name":"Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc Frederick MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erikka","family":"Loftfield","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-9705","authenticated-orcid":false,"given":"Mitchell J.","family":"Machiela","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-2133","authenticated-orcid":false,"given":"Jason Y.Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute Bethesda 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