{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:40:04Z","timestamp":1792870804091,"version":"4.5.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"\n Background<\/jats:title>\n Cardiometabolic comorbidities such as obesity, diabetes, and hypertension are highly prevalent in heart failure (HF). We aimed to examine the association between severity of cardiometabolic comorbidities and hospitalization in patients with HF.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a retrospective electronic health record\u2010based cohort of adults\n \n \n \n \u2265<\/mml:mo>\n <\/mml:mrow>\n $$ \\ge $$<\/mml:annotation>\n <\/mml:semantics>\n <\/mml:math>\n 18 with HF, we categorized individuals based on the number of severe cardiometabolic comorbidities, including hypertension, diabetes, and obesity. Severely uncontrolled comorbidities were defined as systolic blood pressure \u2265160\u2009mm\u2009Hg, hemoglobin A1c \u22658%, and body mass index \u226535\u2009kg\/m\n 2<\/jats:sup>\n . Cox regression models were used to assess the association between cardiometabolic comorbidity burden and time to all\u2010cause and HF hospitalization at 1 year, adjusting for age, sex, race or ethnicity, and insurance status, smoking, prior hospitalization, and Elixhauser comorbidity index. Stratified analyses were conducted for HF with preserved and reduced ejection fraction.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 26\u2009800 individuals with HF (mean age 75\n \n \n \n \u00b1<\/mml:mo>\n <\/mml:mrow>\n $$ \\pm $$<\/mml:annotation>\n <\/mml:semantics>\n <\/mml:math>\n 13.7, 46% women, 69% White) experienced 4284 (16%) hospitalizations over a 1\u2010year period. Compared with individuals with absent comorbidities, those with 1 or 2 to 3 severely uncontrolled comorbidities had a significantly higher risk of all\u2010cause hospitalization (hazard ratio [HR], 1.23 [95% CI, 1.09\u20131.39] and HR, 1.57 [95% CI, 1.35\u20131.83], respectively). We found similar associations for HF hospitalization. These associations were similar among individuals with HF with preserved ejection fraction compared with HF with reduced ejection fraction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Greater cardiometabolic comorbidity burden was associated with increased risk of all\u2010cause hospitalization in HF. This reinforces the role for targeting severely uncontrolled cardiometabolic comorbidities to reduce morbidity in HF.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.036985","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:13:51Z","timestamp":1737612831000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Cardiometabolic Comorbidity Burden and Outcomes in Heart Failure"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-1727","authenticated-orcid":false,"given":"Carine E.","family":"Hamo","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine New York University School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-8544","authenticated-orcid":false,"given":"Xiyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Grossman School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1603-282X","authenticated-orcid":false,"given":"Chiadi E.","family":"Ndumele","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-459X","authenticated-orcid":false,"given":"Amrita","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine New York University School of Medicine New York NY"},{"name":"Department of Population Health New York University Grossman School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-5999","authenticated-orcid":false,"given":"Samrachana","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Grossman School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-1046","authenticated-orcid":false,"given":"Saul","family":"Blecker","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Grossman School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2023.07.006"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.121.021583"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.08.017"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-02076-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1202"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.040"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.092"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.036"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.393"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306963"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(24)02687-1"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.036985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T06:00:30Z","timestamp":1738648830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.036985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,4]]}},"alternative-id":["10.1161\/JAHA.124.036985"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.036985","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e036985"}}