{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:28:00Z","timestamp":1793831280966,"version":"4.6.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Malnutrition status is an important predictor of prognosis in patients after aortic valve replacement. However, the prognostic value of malnutrition status in patients with moderate\u2010to\u2010severe aortic stenosis is unclear. This study aimed to evaluate the effect of malnutrition on all\u2010cause mortality in patients with moderate\u2010to\u2010severe aortic stenosis using the Patient Controlled Nutritional Status (CONUT) score, nutritional risk index, and prognostic nutritional index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 536 patients with moderate\u2010to\u2010severe aortic stenosis were selected in the ARISTOTLE (Aortic Valve Diseases Risk Factor Assessment and Prognosis Model Construction) study conducted between January 2013 and December 2022 in 3 academic institutions. Patients were grouped according to different nutritional status assessment methods. CONUT, nutritional risk index, and prognostic nutritional index were calculated at baseline. The primary study outcome was all\u2010cause mortality. Cox regression was used to assess the association between nutritional status and all\u2010cause mortality. During a median 34.2\u2010month follow\u2010up period, a total of 120 (22.4%) patients died. All\u2010cause mortality was significantly higher in lower prognostic nutritional index, lower nutritional risk index, and higher CONUT groups. Compared with normal nutrition, malnutrition was associated with an increased risk for all\u2010cause death (adjusted hazard ratio for mild and moderate\u2013severe malnutrition, respectively: 2.82 [95% CI, 1.69\u20134.71;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001] and 3.31 [95% CI, 1.74\u20136.32;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001] for the CONUT).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with moderate or severe aortic stenosis, we found that high CONUT scores, low nutritional risk index scores, and low prognostic nutritional index scores were associated with all\u2010cause death. The poorer the nutritional status, the greater the risk of malnutrition\u2010related all\u2010cause mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\u00a0\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT06069232.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037086","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:14:26Z","timestamp":1738577666000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between the Malnutrition Status and All\u2010Cause Mortality in Patients With Moderate and Severe Aortic Stenosis: A\u00a0Prospective Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Bingzhen","family":"Li","sequence":"first","affiliation":[{"name":"Cardiology Department The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-4851","authenticated-orcid":false,"given":"Shaozhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Department The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoguang","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiology Department The First Affiliated Hospital 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