{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:08:56Z","timestamp":1792008536927,"version":"4.4.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study aimed to investigate the hemodynamic and anatomic factors associated with sinus thrombosis following transcatheter aortic valve replacement (TAVR), integrating in\u00a0vivo patient data analysis and in\u00a0vitro experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Postprocedural, 4\u2010dimensional, multiphase computed tomography data from 211 patients enrolled in the ADAPT\u2010TAVR (Anticoagulation Versus Dual Antiplatelet Therapy for Prevention of Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement) study were analyzed. The prevalence of native sinus thrombosis was examined in relation to valve type, implant depth, and anatomic features. In\u00a0vitro experiments used particle image velocimetry to observe changes in sinus flow based on the transcatheter heart valves (23\u2010mm SAPIEN3, Edwards Lifesciences; and 29\u2010mm CoreValve, Medtronic) height and coronary artery flow. Native sinus thrombosis was more common in self\u2010expanding valves (39.1% versus 14.9%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004). In per\u2010cusp analysis of in\u00a0vivo patient data, adjusted transcatheter heart valve implant depth (odds ratio, 1.2 [95% CI, 1.1\u20131.3];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), noncoronary sinus of Valsalva (odds ratio, 4.0 [95% CI, 2.0\u20137.8];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), sinus inflow diameter (odds ratio, 0.8 [95% CI, 0.6\u20130.9];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008), and implanted valve size (odds ratio, 0.8 [95% CI, 0.7\u20131.0];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.025) were significant factors associated with native sinus thrombosis. In the in\u00a0vitro experiments, CoreValve showed noticeable flow stasis compared with SAPIEN3. High\u2010positioned SAPIEN3 was linked to reduced velocity within the native sinus of Valsalva. Coronary artery flow led to higher sinus velocity and improved particle washout, reducing sinus thrombosis risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study provides insights into the relationship between transcatheter heart valve deployment and native sinus thrombosis, emphasizing the role of anatomic factors in relation to the risk of sinus thrombosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037105","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:04:42Z","timestamp":1729839882000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Native Sinus Hemodynamics and Thrombosis in Transcatheter Heart Valve: Effect of Implant Depth and Coronary Flow"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-3835","authenticated-orcid":false,"given":"Hyun Jung","family":"Koo","sequence":"first","affiliation":[{"name":"University of Ulsan College of Medicine, Asan Medical Center","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-6651","authenticated-orcid":false,"given":"Jihun","family":"Kang","sequence":"additional","affiliation":[{"name":"Kangwon National University","place":["Chuncheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-0562","authenticated-orcid":false,"given":"Do\u2010Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"University of Ulsan College of Medicine, Asan Medical Center","place":["Seoul, South 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High Transcatheter valve replacement may reduce washout in the aortic sinuses: an in\u2010vitro study. 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