{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:48Z","timestamp":1753889748237,"version":"3.41.2"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although most children with congenital heart defects (CHDs) live into adulthood, many have increased mortality risk across the lifespan. Little is known about years lost due to premature CHD\u2010related deaths. We estimated the years of potential life lost (YPLL) among individuals with CHDs in the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We used 2007 to 2017 death records from the US National Center for Health Statistics to identify decedents with a CHD listed as the underlying or contributing cause of death. We calculated the average percent change in YPLL and the total, mean, crude, and age\u2010standardized YPLL overall, by sex, race and ethnicity, and age group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Of 28.35 million deaths, 42\u2009158 were CHD\u2010related. The premature deaths attributed to CHD for individuals younger than 65\u2009years was almost 2.1 million years; of those 169\u2009756 and 124\u2009067\u2009years were lost prematurely for children and adolescents, respectively. Men and women with CHDs had 1.13 million and 941\u2009115\u2009years lost prematurely, respectively. Non\u2010Hispanic Black individuals and men had the highest age\u2010standardized YPLL (per 100\u2009000) (95.5 [95% CI, 93.2\u201397.7] and 74.1 [95% CI, 73.0\u201375.1]). The overall mean YPLL was 70\u2009years (per 100\u2009000) and non\u2010Hispanic Black men and women had the highest mean YPLL. During 2007 to 2017, the YPLL average percent change declined by 17.8% overall, but the YPLL for non\u2010Hispanic Black individuals aged 1 to 4\u2009years (\u221231.6%) and 35 to 49\u2009years (\u221224.3%) had the greatest decline.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Children with CHDs experience significant premature deaths. Non\u2010Hispanic Black and male individuals\u00a0experienced the highest burden of premature deaths associated with CHDs. Further research is needed to elucidate these disparities.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037164","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:30:10Z","timestamp":1741861810000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Years of Potential Life Lost for Children and Adults With Congenital Heart Defects: United States, 2007 to 2017"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4049","authenticated-orcid":false,"given":"Wendy N.","family":"Nembhard","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]},{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-536X","authenticated-orcid":false,"given":"Suman","family":"Maity","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]},{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-3470","authenticated-orcid":false,"given":"Emine","family":"Bircan","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]},{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-8383","authenticated-orcid":false,"given":"Maria D.","family":"Politis","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-2611","authenticated-orcid":false,"given":"Elijah H.","family":"Bolin","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]},{"name":"University of Arkansas for Medical Sciences and Arkansas Children\u2019s Hospital","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7693-4243","authenticated-orcid":false,"given":"Jun","family":"Ying","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]},{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199707\/08)56:1\/2<8::AID-TERA3>3.0.CO;2-U"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1326901"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1997)14:5<493::AID-GEPI4>3.0.CO;2-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06490-8"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.068"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1073"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.881904"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-009-3169-x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90001-1"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.11.014"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0221-z"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10119"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14017430410024379"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36830-4"},{"key":"e_1_3_1_16_2","first-page":"442","article-title":"Racial\/ethnic disparities in mortality related to congenital heart defects among children and adults in the United States","volume":"18","author":"Nembhard WN","year":"2008","unstructured":"Nembhard WN, Pathak EB, Schocken DD. 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