{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:49:05Z","timestamp":1791298145945,"version":"4.1.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The exercise assessment of the right ventricular\u2010pulmonary arterial (PA) coupling adds diagnostic and prognostic value in patients with heart failure. In patients with ischemic mitral regurgitation undergoing surgery, data on the exercise assessment of the right ventricular\u2010PA coupling are not available. Resting and exercise echocardiographic predictors of functional outcome in patients with ischemic mitral regurgitation were tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Six\u2010minute walking test and exercise echocarrdiogram performed at baseline, at 1\u2009years, and at a median follow\u2010up of 6\u2009years (interquartile range, 3.70; range, 4.5\u20138) on 50 patients (67\u00b18\u2009years; ejection fraction: 35\u00b15%) undergoing valve replacement or repair. Linear mixed models were used to evaluate the predictive value of preoperative echocardiographic parameters on the longitudinal distribution of the 6\u2010minute walking test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Preoperative exercise tricuspid annular plane systolic excursion (TAPSE)\/PA systolic pressure strongly correlated with the long\u2010term 6\u2010minute walking test (r=0.81,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). The receiver operating characteristic analysis found a preoperative exercise TAPSE\/PA systolic pressure &lt;0.34 predicted the lowest quartile of the 6\u2010minute walking test in the long term (sensitivity: 79%; specificity: 100%) as well as a composite outcome of heart failure and death from any cause (positive predictive value: 91.3%, negative predictive value: 100%). On multivariable analysis, TAPSE and TAPSE\/PA systolic pressure were significantly associated with a better long\u2010term 6\u2010minute walking test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">A preoperative exercise TAPSE\/PA systolic pressure &lt;0.34 predicts a poor functional performance and a higher likelihood of clinical adverse events. In patients with ischemic mitral regurgitation the exercise right ventricular \u2010PA coupling could improve risk stratification. Larger studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037198","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:21:30Z","timestamp":1744348890000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Exercise Right Ventricular\u2010Pulmonary Arterial Coupling and Functional Outcome in Patients Undergoing Surgery for Secondary Ischemic Mitral Regurgitation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-849X","authenticated-orcid":false,"given":"Carlo","family":"Fino","sequence":"first","affiliation":[{"name":"Ospedale Papa Giovanni XXIII","place":["Bergamo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-2868","authenticated-orcid":false,"given":"Diego","family":"Bellavia","sequence":"additional","affiliation":[{"name":"Mediterranean 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