{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:58:40Z","timestamp":1792447120712,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,20]]},"abstract":"<jats:sec id=\"jah310828-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Takotsubo cardiomyopathy continues to be a major cause of mortality and morbidity. The goal of this study was to evaluate the outcome data of patients with Takotsubo cardiomyopathy using a large inpatient database.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310828-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We used the Nationwide Inpatient Sample database for our study. We evaluated trends, mortality, and complications of patients admitted with Takotsubo cardiomyopathy from available years 2016 to 2020 in adults &gt;18. A total of 199\u2009890 patients with Takotsubo were found in our database with 83% being female and higher prevalence with age, White race, and highest income. Mortality was high at 6.5% with no significant improvement over the years studied. Furthermore, major complications were substantial. Cardiogenic shock occurred in 6.6%, atrial fibrillation in 20.7%, cardiac arrest in 3.4%, congestive heart failure in 35.9%, and stroke in 5.3%. Mortality was more than double in men in comparison to women (11.2% versus 5.5%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310828-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Takotsubo cardiomyopathy is associated with high mortality and complications with no improvement in outcome over the 5\u2010year study with higher mortality in men. Further improvement in care is needed to improve outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037219","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:11:14Z","timestamp":1747217474000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["High Mortality and Complications in Patients Admitted With Takotsubo Cardiomyopathy With More Than Double Mortality in Men Without Improvement in Outcome Over the Years"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-0510","authenticated-orcid":false,"given":"Mohammad Reza","family":"Movahed","sequence":"first","affiliation":[{"name":"University of Arizona Sarver Heart Center","place":["Tucson, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elimira","family":"Javanmardi","sequence":"additional","affiliation":[{"name":"University of Arizona Sarver Heart Center","place":["Tucson, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-8709","authenticated-orcid":false,"given":"Mehrtash","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"University of Arizona","place":["Phoenix, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311579"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055854"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.366"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12664"},{"key":"e_1_3_1_6_2","unstructured":"Gacutan K. 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