{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:35:26Z","timestamp":1792485326329,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The comparison of coronary computed tomography angiography plaques and perivascular adipose tissue (PVAT) between patients with acute myocardial infarction (AMI) posttreatment and patients with stable coronary artery disease is poorly understood. Our objective was to evaluate the differences in coronary computed tomography angiography\u2013quantified plaque and PVAT characteristics in patients post\u2010AMI and identify signs of residual inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed 205 patients (age, 59.77\u00b19.24\u2009years; 92.20% men) with AMI \u22641\u2009month and matched them with 205 patients with stable coronary artery disease (age, 60.52\u00b110.04\u2009years; 90.24% men) based on age, sex, and cardiovascular risk factors. Coronary computed tomography angiography scans were assessed for nonculprit plaque and vessel characteristics, plaque volumes by composition, high\u2010risk plaques, and PVAT mean attenuation. Both patient groups exhibited similar noncalcified plaque volumes (383.35\u00b1313.23 versus 378.63\u00b1426.25\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.899). However, multivariable analysis revealed that patients post\u2010AMI had a greater patient\u2010wise noncalcified plaque volume ratio (estimate, 0.089 [95% CI, 0.053\u20130.125],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), largely attributed to a higher fibrofatty and necrotic core volume ratio, along with higher peri\u2010lesion PVAT mean attenuation (estimate, 3.968 [95% CI, 2.556\u20135.379],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). When adjusted for vessel length, patients post\u2010AMI had more high\u2010risk plaques (estimate, 0.417 [95% CI, 0.298\u20130.536],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) per patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients post\u2010AMI displayed heightened noncalcified plaque components, largely due to fibrofatty and necrotic core content, more high\u2010risk plaques, and increased PVAT mean attenuation on a per\u2010patient level, highlighting the necessity for refined risk assessment in patients with AMI after treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037258","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:50:47Z","timestamp":1730188247000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Characterizing Nonculprit Lesions and Perivascular Adipose Tissue of Patients Following Acute Myocardial Infarction Using Coronary Computed Tomography Angiography: A Comparative Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-4109","authenticated-orcid":false,"given":"Xiaomeng","family":"Wang","sequence":"first","affiliation":[{"name":"Duke\u2010National University of Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-2869","authenticated-orcid":false,"given":"Ching H.","family":"Sia","sequence":"additional","affiliation":[{"name":"National University Heart Center Singapore","place":["Singapore"]},{"name":"National University of Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-956X","authenticated-orcid":false,"given":"Philip D.","family":"Adamson","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch","place":["New Zealand"]},{"name":"University of Edinburgh","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-5355","authenticated-orcid":false,"given":"Charlotte E.","family":"Greer","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute for Infocomm Research, Agency for Science, Technology and Research (A*Star)","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-5377","authenticated-orcid":false,"given":"Hwee K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Agency for Science, Technology and Research (A*Star)","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Leng","sequence":"additional","affiliation":[{"name":"National Heart Center Singapore","place":["Singapore"]},{"name":"Duke\u2010National University of Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan T.","family":"Loong","sequence":"additional","affiliation":[{"name":"National Heart Center Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur A. S.","family":"Raffiee","sequence":"additional","affiliation":[{"name":"National Heart Center Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee Y.","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke\u2010National University of Singapore","place":["Singapore"]},{"name":"National Heart Center Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-2083","authenticated-orcid":false,"given":"Sock H.","family":"Tan","sequence":"additional","affiliation":[{"name":"National University of Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-9458","authenticated-orcid":false,"given":"Lynette L. S.","family":"Teo","sequence":"additional","affiliation":[{"name":"National University Hospital","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-8275","authenticated-orcid":false,"given":"Sung L.","family":"Wong","sequence":"additional","affiliation":[{"name":"National Heart Center Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-2040","authenticated-orcid":false,"given":"Xiaoxun","family":"Yang","sequence":"additional","affiliation":[{"name":"National University of Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-5864","authenticated-orcid":false,"given":"Min S.","family":"Yew","sequence":"additional","affiliation":[{"name":"Tan Tock Seng Hospital","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-5351","authenticated-orcid":false,"given":"Thon H.","family":"Yong","sequence":"additional","affiliation":[{"name":"Changi General Hospital","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-4173","authenticated-orcid":false,"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Duke\u2010National University of Singapore","place":["Singapore"]},{"name":"National Heart Center Singapore","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1491","authenticated-orcid":false,"given":"Leslee J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-7450","authenticated-orcid":false,"given":"Mark Y. 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