{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:58:21Z","timestamp":1790949501638,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah310490-sec-0001\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Symptom burden and disease effects following myocardial infarction with nonobstructive coronary arteries (MINOCA) are not well studied. We aimed to evaluate the prevalence of angina pectoris, sick leave, and quality\u2010of\u2010life levels 1\u2009year after the index event, using patients with myocardial infarction due to obstructive coronary artery disease (MI\u2010CAD) as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah310490-sec-0002\" xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients with first\u2010time myocardial infarction, assessed by coronary angiography and registered in the SWEDEHEART (Swedish Web\u2010System for Enhancement and Development of Evidence\u2010Based Care in Heart Disease Evaluated According to Recommended Therapies) registry 2005 to 2022 were eligible and included if attending the 1\u2010year follow\u2010up. Patients with previous coronary intervention, heart failure, arrhythmia at admission, and not fully revascularized MI\u2010CAD were excluded. Outcomes were prospectively collected during standard care. A total of 46\u2009428 patients (mean age, 62\u2009years; 71% men; MINOCA, n=5281\/MI\u2010CAD, n=41\u2009157) were assessed after 1\u2009year. Angina prevalence was 11.6% in MINOCA and 8.8% in fully revascularized MI\u2010CAD (crude risk ratio, 1.32 [95% CI, 1.21\u20131.47]; odds ratio, 1.18 [95% CI, 1.07\u20131.30], adjusted for potential confounders). Patients with MINOCA had a higher degree of sick leave than patients with MI\u2010CAD both at index care and at 1\u2009year (8.0% versus 5.6% and 13.4% versus 10.9%, respectively; both\n                      <jats:italic toggle=\"no\">P&lt;<\/jats:italic>\n                      0.001). Quality\u2010of\u2010life measures were lower in MINOCA. These associations were unaffected when adjusting for angina status but were attenuated when adjusting for potential confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah310490-sec-0003\" xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with MINOCA have significant distress, with higher levels of angina pectoris and sick leave and worse quality of life at 1\u2009year compared with fully revascularized MI\u2010CAD counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037264","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T10:19:17Z","timestamp":1752488357000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Angina Pectoris Prevalence and Sick Leave Burden 1 Year After Myocardial Infarction With Nonobstructive Coronary Arteries"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-9495","authenticated-orcid":false,"given":"Kerstin","family":"Wel\u00e9n Schef","sequence":"first","affiliation":[{"name":"Danderyd Hospital, Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-1338","authenticated-orcid":false,"given":"Per","family":"Tornvall","sequence":"additional","affiliation":[{"name":"S\u00f6dersjukhuset, Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-0061","authenticated-orcid":false,"given":"Bertil","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[{"name":"\u00d6rebro University","place":["\u00d6rebro, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-379X","authenticated-orcid":false,"given":"Tomas","family":"Jernberg","sequence":"additional","affiliation":[{"name":"Danderyd Hospital, Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004185"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000670"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.027666"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12857"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcv014"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.118.009174"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.04.040"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcac072"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.09.047"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.020535"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.10.023"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.198804"},{"key":"e_1_3_1_14_2","unstructured":"Vasko P Alfredsson J B\u00e4ck M Dahlbom L Engblom H Erlinge D Ernkvist M Friberg \u00d6 Hagstr\u00f6m E Johansson P et\u00a0al. SWEDEHEART annual report 2022. In: https:\/\/www.ucr.uu.se\/swedeheart\/dokument\u2010sh\/arsrapporter\u2010sh\/arsrapport\u20102022\/01\u2010swedeheart\u2010annual\u2010report\u20102022\u2010english\u20102: Uppsala Clinical Research Center (UCR);2023."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw149"},{"key":"e_1_3_1_16_2","first-page":"371","article-title":"The Canadian cardiovascular society grading of angina pectoris revisited 30\u2009years later","volume":"18","author":"Campeau L","year":"2002","unstructured":"Campeau L. The Canadian cardiovascular society grading of angina pectoris revisited 30\u2009years later. Can J Cardiol. 2002;18:371\u2013379.","journal-title":"Can J Cardiol"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.7478"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311950"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.05.001"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.02.021"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01472-4"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-49223-w"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-22-00178"},{"key":"e_1_3_1_25_2","unstructured":"Tornvall P. Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3 (SMINC\u20103). In: ClinicalTrials.gov ID NCT05426408;2023."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T10:11:25Z","timestamp":1752660685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":24,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7,15]]}},"alternative-id":["10.1161\/JAHA.124.037264"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037264","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2024-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037264"}}