{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:11:06Z","timestamp":1763338266650,"version":"3.41.2"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,12,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although a high pulse rate assessed in the clinic office setting has been associated with an increased risk of cardiovascular disease and mortality, there are few studies assessing the prognostic ability of out\u2010of\u2010office pulse rate, particularly self\u2010measured home pulse rate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We investigated the prognostic ability of home pulse rate in 3022 patients with mild\u2010to\u2010moderate hypertension. During a median follow\u2010up of 7.3\u2009years, 72 patients died and 50 had major adverse cardiovascular events. For each 1 SD increase in pulse rate before treatment (9.4\u2009beats per minute), the adjusted hazard ratio for all\u2010cause mortality was 1.52 (95% CI, 1.24\u20131.92). For each 1 SD increase in pulse rate during the follow\u2010up period (9.9\u2009beats per minute), the adjusted hazard ratio was 1.70 (95% CI, 1.39\u20132.08). However, pulse rate was not significantly associated with major adverse cardiovascular events. When both home pulse rate and office pulse rate before treatment were included in a Cox model, only the home pulse rate significantly predicted all\u2010cause mortality (\n              <jats:italic>P<\/jats:italic>\n              \u22640.019). Excluding the home pulse rate from the model led to a significant deterioration of the model fit statistic (\n              <jats:italic>P<\/jats:italic>\n              \u22640.020). The optimal cut\u2010off values of home pulse rate in predicting all\u2010cause mortality, determined by Youden's index from a receiver operator characteristic analysis, were 67.8\u2009beats per minute at baseline and 66.4 beats per minute during follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with mild\u2010to\u2010moderate hypertension, the pulse rate measured at home, both before and during antihypertensive treatment, was associated with mortality risk and has superior prognostic ability compared with office pulse rate. The accuracy of risk stratification may be improved by using a home pulse rate, which can be self\u2010measured easily and frequently at home.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\">https:\/\/www.umin.ac.jp\/ctr<\/jats:ext-link>\n              ; Unique identifier: C000000137.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037292","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T09:19:07Z","timestamp":1734167947000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Home Pulse Rate Before and During Antihypertensive Treatment and Mortality Risk in Hypertensive Patients: A Post Hoc Analysis of the HOMED\u2010BP Study"],"prefix":"10.1161","volume":"13","author":[{"given":"Takahiro","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health Teikyo University School of Medicine Tokyo Japan"},{"name":"Fourth Department of Internal Medicine Mizonokuchi Hospital, Teikyo University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-6107","authenticated-orcid":false,"given":"Masahiro","family":"Kikuya","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Teikyo University School of Medicine Tokyo Japan"},{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-0547","authenticated-orcid":false,"given":"Kei","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Teikyo University School of Medicine Tokyo Japan"},{"name":"Environment and Health KU Leuven Department of Public Health and Primary Care Leuven Belgium"},{"name":"Tohoku Institute for Management of Blood Pressure Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Teikyo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Imai","sequence":"additional","affiliation":[{"name":"Tohoku Institute for Management of Blood Pressure Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-8196","authenticated-orcid":false,"given":"Takayoshi","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Teikyo University School of Medicine Tokyo Japan"},{"name":"Tohoku Institute for Management of Blood Pressure Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90128-v"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.12.020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.1.44"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110985"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312452501"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001364"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.20.2313"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000000865"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000596"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283041172"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.103"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs449"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.06.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.771"},{"key":"e_1_3_2_18_2","volume-title":"The National Health and Nutrition Survey in Japan, 2010","author":"The Ministry of Health, Labour and Welfare","year":"2012","unstructured":"The Ministry of Health, Labour and Welfare . The National Health and Nutrition Survey in Japan, 2010. The Ministry of Health, Labour and Welfare; 2012."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.125"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200202000-00016"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0050-4"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-00860-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200108000-00008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000002998"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6687.1552"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200104000-00007"},{"key":"e_1_3_2_27_2","first-page":"611","article-title":"Heart rate and prostate cancer mortality: results of a prospective analysis","volume":"4","author":"Gann PH","year":"1995","unstructured":"Gann PH, Daviglus ML, Dyer AR, Stamler J. Heart rate and prostate cancer mortality: results of a prospective analysis. Cancer Epidemiol Biomarkers Prev. 1995;4:611\u2013616.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.Epi-20-1731"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2017.04.004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.11.007"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0430-3"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.1051"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.04.009"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002523"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2023.105218"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.122.060291"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000003483"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:52:36Z","timestamp":1734439956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":36,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,12,17]]}},"alternative-id":["10.1161\/JAHA.124.037292"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037292","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037292"}}