{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:50Z","timestamp":1788876590140,"version":"build-2803163510"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Therefore, we examined the additional value of circulating fibrosis markers as a putative biomarker platform to identify patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) who are at a higher risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this study, 2\u2010year survival analyses were conducted in 378 consecutive patients undergoing TAVR to evaluate the association between fibrosis marker and risk of adverse long\u2010term outcome. Implementation of fibrosis marker into TAVR risk stratification was tested by a machine\u2010learning algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 20 circulating fibrosis markers involved in pathological extracellular matrix remodeling, high tissue inhibitor of metalloproteinase\u20101 (TIMP\u20101) levels independently predicted risk of death in univariable (hazard ratio, 5.0 [95% CI, 2.6\u20139.7];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and multivariable (adjusted hazard ratio, 2.2 [95% CI, 1.0\u20134.7];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.046) Cox regression analyses. Consequently, higher TIMP\u20101 levels offered a significantly higher overall prediction of reduced survival compared with the conventional Society of Thoracic Surgeons Predicted Risk of Mortality score (area under the curve, 0.753 [95% CI, 0.682\u20130.824] versus area under the curve, 0.656 [95% CI, 0.578\u20130.734];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Applying an independent machine\u2010learning algorithm allowed identification of a simple combination of 2 biomarkers (TIMP\u20101 and high\u2010sensitivity cardiac troponin T) with superior prognostic value compared with Society of Thoracic Surgeons Predicted Risk of Mortality alone (area under the curve, 0.757 [95% CI, 0.686\u20130.828] versus 0.656 [95% CI, 0.578\u20130.34];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Circulating TIMP\u20101 is an independent predictor of reduced 2\u2010year overall survival in patients undergoing TAVR. Combined with high\u2010sensitivity cardiac troponin T, circulating TIMP\u20101 should be incorporated into risk stratification to identify patients undergoing TAVR who are at a higher risk of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037296","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:04:37Z","timestamp":1740549877000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Extracellular Matrix Proteins Improve Risk Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"14","author":[{"given":"Felicitas","family":"Boeckling","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Rasper","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Zanders","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Pergola","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Cremer","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-8180","authenticated-orcid":false,"given":"Silvia","family":"Mas\u2010Peiro","sequence":"additional","affiliation":[{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariuca","family":"Vasa\u2010Nicotera","sequence":"additional","affiliation":[{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-420X","authenticated-orcid":false,"given":"David","family":"Leistner","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-2436","authenticated-orcid":false,"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-5536","authenticated-orcid":false,"given":"Badder","family":"Kattih","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt, University Hospital","place":["Frankfurt, Germany"]},{"name":"Partner Site Frankfurt Rhine\u2010Main","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.033048"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.121.022792"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.5742"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs468"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.04.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.08.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.064"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.032839"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1616598"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad140"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa033"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-17-00421"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.056"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1389107"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw456"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12837"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-18-00059"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.11.101"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.108"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.10.022"},{"key":"e_1_3_2_23_2","first-page":"714","article-title":"Role of PDGFR\u2010\u03b2\/PI3K\/AKT signaling pathway in PDGF\u2010BB induced myocardial fibrosis in rats","volume":"6","author":"Fan H","year":"2014","unstructured":"Fan H, Ma L, Fan B, Wu J, Yang Z, Wang L. Role of PDGFR\u2010\u03b2\/PI3K\/AKT signaling pathway in PDGF\u2010BB induced myocardial fibrosis in rats. Am J Transl Res. 2014;6:714\u2013723.","journal-title":"Am J Transl Res"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512818200"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105548"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.118.11874"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-012-9446-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa324"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.119.311148"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.030178"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.032951"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqad055"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab869"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr511"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1008311"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx510"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.912774"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.077"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.515106"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000024573.17293.23"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(01)02316-0"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.600353"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.516963"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.09045"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00511.2002"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00370.2004"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048851"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2302062"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt132"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.07.003"},{"key":"e_1_3_2_53_2","first-page":"109","article-title":"The Society of Thoracic Surgery Risk Score as a predictor of 30\u2010day mortality in transcatheter vs surgical aortic valve replacement: a single\u2010center experience and its implications for the development of a TAVR risk\u2010prediction model","volume":"29","author":"Balan P","year":"2017","unstructured":"Balan P, Zhao Y, Johnson S, Arain S, Dhoble A, Estrera A, Smalling R, Nguyen TC. The Society of Thoracic Surgery Risk Score as a predictor of 30\u2010day mortality in transcatheter vs surgical aortic valve replacement: a single\u2010center experience and its implications for the development of a TAVR risk\u2010prediction model. J Invasive Cardiol. 2017;29:109\u2013114.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000932"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.7754\/clin.lab.2013.130346"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070179"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00031"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv756"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:37:06Z","timestamp":1788874626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,4]]}},"alternative-id":["10.1161\/JAHA.124.037296"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037296","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"2024-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037296"}}