{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:03:33Z","timestamp":1784117013953,"version":"3.55.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To evaluate, in a cohort study, whether coronary microvasculature and myocardial structure differ between people with and without coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed histological analysis of left ventricle free wall obtained at autopsy from 25 men and 23 women with \u22651 coronary artery with \u226575% area stenosis, and 25 men and 25 women without (no or minimal) CAD, matched for sex and age, who died suddenly from noncardiac causes. Decedents with myocardial infarction or other cardiac abnormality were excluded. Decedents with and without CAD had similar height and weight. Heart weight of decedents with CAD was higher than that of decedents without CAD (mean, 391 versus 364\u2009g; mean difference, 27\u2009g [95% CI, 0.3\u201354.0],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.048). Decedents with CAD had lower arteriole density (mean, 1.4 per mm\n                      <jats:sup>2<\/jats:sup>\n                      versus 1.8 per mm\n                      <jats:sup>2<\/jats:sup>\n                      ; mean difference, \u22120.4 per mm\n                      <jats:sup>2<\/jats:sup>\n                      [95% CI, \u22120.6 to \u22120.2],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0001), lower capillary length density (mean, 3164 versus 3701\u2009mm\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ; mean difference, \u2212537 [95% CI, \u2212787 to \u2212286],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001), and higher total myocardial fibrosis (mean, 7.5% versus 5.7%; mean difference, 1.7% [95% CI, 1.0\u20132.5],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001), than decedents without CAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">CAD was associated with coronary microvascular rarefaction and increased myocardial fibrosis. The association of CAD with coronary microvascular rarefaction and increased myocardial fibrosis may contribute to the increased risks of death, myocardial infarction and heart failure that accompany CAD, and may attenuate the impact of percutaneous coronary intervention on cardiovascular risk in people with stable angina.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037332","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T21:34:22Z","timestamp":1729287262000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association of Coronary Microvascular Rarefaction and Myocardial Fibrosis With Coronary Artery Disease"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6896-7571","authenticated-orcid":false,"given":"Duncan J.","family":"Campbell","sequence":"first","affiliation":[{"name":"St. Vincent\u2019s Institute of Medical Research","place":["Fitzroy, Australia"]},{"name":"University of Melbourne","place":["Parkville, Australia"]},{"name":"St. Vincent\u2019s Hospital","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-8460","authenticated-orcid":false,"given":"Victoria C. M.","family":"Francis","sequence":"additional","affiliation":[{"name":"Monash University","place":["Southbank, Australia"]},{"name":"Victorian Institute of Forensic Medicine","place":["Southbank, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6013-528X","authenticated-orcid":false,"given":"Gregory R.","family":"Young","sequence":"additional","affiliation":[{"name":"Monash University","place":["Southbank, Australia"]},{"name":"Victorian Institute of Forensic Medicine","place":["Southbank, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8867-5925","authenticated-orcid":false,"given":"Noel W. F.","family":"Woodford","sequence":"additional","affiliation":[{"name":"Monash University","place":["Southbank, Australia"]},{"name":"Victorian Institute of Forensic Medicine","place":["Southbank, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.005375"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.25"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2000239"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070829"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805796"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911669"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505532"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915922"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206606"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062714"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048194"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199206001-00010"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy169"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz389"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx721"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12082964"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.031373"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90172-W"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90348-g"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00359-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht513"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1111721"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(41)90726-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.86.1.38"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.075"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009625"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.064"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2221-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.165043"},{"key":"e_1_3_2_33_2","first-page":"545","article-title":"A simple method for the silver impregnation of reticulin","volume":"12","author":"Gordon H","year":"1936","unstructured":"Gordon H, Sweets HH. 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