{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:46:46Z","timestamp":1777895206952,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The early assessment of heart failure (HF) risk in patients with acute coronary syndrome (ACS) can help reduce mortality. S100A8\/A9 is not only rapidly released after myocardial ischemia, but is also involved in reperfusion injury, which is an important predictor of HF after ACS. We attempted to construct a reliable HF risk stratification tool for evaluating patients with ACS after reperfusion therapy based on S100A8\/A9 dynamic changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This prospective study included 3 independent cohorts of patients with ACS who received reperfusion therapy. The discovery cohort was divided into 2 subgroups: the longitudinal subgroup (n=264) with serum S100A8\/A9 levels measured at admission and on days 1, 2, 3, and 4 postadmission, respectively, and the 2\u2010point subgroup (n=798) with S100A8\/A9 levels measured at admission and on day 1 postadmission, respectively. Validation cohorts 1 (n=1399) and 2 (n=1183) both had S100A8\/A9 levels measured on day 1 postadmission. HF events included in\u2010hospital HF events after the initial presentation and long\u2010term HF events after discharge. The median follow\u2010up for the discovery cohort, validation cohort 1, and validation cohort 2 was 4.2, 2.6, and 1.8\u2009years, respectively. In the discovery cohort, S100A8\/A9's predictive ability at day 1 surpassed other time points. Through the S100A8\/A9\u2010guided risk stratification, patients deemed high risk (&gt;7900\u2009ng\/mL) exhibited a higher 1\u2010year HF event rate (46% versus 2%, 38% versus 5%) than patients at low risk (&lt;2100\u2009ng\/mL) in both validation cohorts. Among patients without left ventricular dysfunction after ACS, \u03b2\u2010blocker therapy correlated with reduced 1\u2010year HF events in intermediate\u2010to\u2010 high\u2010risk patients but not in low\u2010risk patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">S100A8\/A9 levels on day 1 accurately classified patients at varying risks of HF, serving as a robust tool for HF risk prediction and treatment guidance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03752515.\n            <\/jats:p>\n      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Hospital of Capital Medical University Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-0873","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital of Capital Medical University Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital of Capital Medical University Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital of Capital Medical University Beijing 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