{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:44:51Z","timestamp":1782992691962,"version":"3.54.5"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Available data about sex differences in patients with acute aortic dissection (AAD) are scant and conflicting. The aim of this study is to assess sex\u2010related differences in clinical characteristics, presentation, diagnostic findings, management, and outcomes among patients with type A (TA\u2010AAD) and type B AAD (TB\u2010AAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Data about 11\u2009586 patients enrolled in the IRAD (International Registry of Acute Aortic Dissection) from 1996 to 2022, were analyzed; 7819 (67.5%) experienced TA\u2010AAD and 3867 (33.0%) TB\u2010AAD. Men and women were compared with regard to diagnosis, treatment, and in\u2010hospital and long\u2010term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      One third of patients were women (TA\u2010AAD, 34.4%; and TB\u2010AAD, 34.5%). Women were older than men for both types of AAD. The median time from hospital admission to diagnosis was longer in women for both TA\u2010AAD and TB\u2010AAD (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). For TA\u2010AAD, symptoms of hypotension and coma\/altered mental status were more common in women, whereas for TB\u2010AAD women were more likely to present with congestive heart failure. Surgical repair for TA\u2010AAD was less frequent in women than men (84.6% versus 89.0%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). For both types of AAD, medical management was more common among women than men (TA\u2010AAD, 16.5% versus 11.6%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001; TB\u2010AAD, 65.6% versus 54.2%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The overall as well as surgical in\u2010hospital mortality rate was higher among women with TA\u2010AAD compared with men (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), whereas it was similar in those managed medically (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.23). No difference in overall (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =1), medical (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.38), endovascular (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =1), and surgical (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.51) mortality rates was observed for TB\u2010AAD between men and women. After TA\u2010AAD, women showed lower 4\u2010year survival compared with men (81.4% versus 86.6%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The present study highlights important sex\u2010related differences in AAD; there is a need to design tailored aortic disease management programs to improve outcomes in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037506","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:17:52Z","timestamp":1772101072000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Sex\u2010Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-0418","authenticated-orcid":false,"given":"Elizabeth","family":"Jackson","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham","place":["Birmingham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-7010","authenticated-orcid":false,"given":"Andreina","family":"Carbone","sequence":"additional","affiliation":[{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-2750","authenticated-orcid":false,"given":"Sherene","family":"Shalhub","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine","place":["Seattle, USA"]},{"name":"Oregon Health and Science University","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-5947","authenticated-orcid":false,"given":"Chih\u2010Wen","family":"Pai","sequence":"additional","affiliation":[{"name":"University of Michigan","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-5788","authenticated-orcid":false,"given":"Marek","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-664X","authenticated-orcid":false,"given":"Toru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital","place":["Leicester, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-3785","authenticated-orcid":false,"given":"G. Chad","family":"Hughes","sequence":"additional","affiliation":[{"name":"Duke University Medical Center","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhan","sequence":"additional","affiliation":[{"name":"Medanta The Medicity","place":["Gurgaon, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-3527","authenticated-orcid":false,"given":"Rumi","family":"Faizer","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cittadini","sequence":"additional","affiliation":[{"name":"Federico II University","place":["Naples, Italy"]},{"name":"Federico II University","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-310X","authenticated-orcid":false,"given":"Alan","family":"Braverman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine","place":["St. Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-168X","authenticated-orcid":false,"given":"Eric","family":"Isselbacher","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0191","authenticated-orcid":false,"given":"Kim","family":"Eagle","sequence":"additional","affiliation":[{"name":"University of Michigan Health System","place":["Ann Arbor, 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