{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:50:19Z","timestamp":1753883419791,"version":"3.41.2"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The diagnostic role of signal\u2010averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG\u2010derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with definite ARVC diagnosis or genotype\u2010positive family members who underwent SAECG were included in register\u2010based observational study (n=357, mean age 41\u2009years, 47% female, 43% probands). LP and terminal activation duration (TAD) were defined by Task Force Criteria 2010. We assessed the association of TAD and LP with structural RV abnormalities and ventricular tachycardia (VT), defined as sustained VT, appropriate implantable cardioverter\u2010defibrillator shock, aborted cardiac arrest, or sudden cardiac death, at diagnosis. LP were documented in 210 patients (59%) and abnormal TAD in 66 patients (18%). Each of the SAECG parameters was significantly associated with definite ARVC diagnosis in receiver\u2010operator characteristics curve analysis with area under the curve between 0.67 and 0.74. Exclusion of SAECG from diagnostic workup led to reclassification of 37 patients (16%) from definite to borderline ARVC (13 probands, 9 of whom had prevalent VT). Ninety patients (25%) had history of VT. LP, but not TAD, were associated with VT (adjusted odds ratio [OR\n              <jats:sub>adj<\/jats:sub>\n              ], 2.42 [95%CI, 1.07\u20135.48]). LP had lower specificity (72% versus 97%) but higher sensitivity (71% versus 25%) for association with RV structural abnormalities than TAD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In the Nordic ARVC cohort SAECG\u2010derived LP are associated with VT and structural RV abnormalities and were critical for ascertainment of ARVC diagnosis in 16% of patients with narrow QRS complexes, including 8% of all probands.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037544","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T04:45:16Z","timestamp":1741409116000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Signal\u2010Averaged ECG in the Diagnostic Workup for Arrhythmogenic Cardiomyopathy: Insights From the Nordic ARVC Registry"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-7525","authenticated-orcid":false,"given":"Aleksei A.","family":"Savelev","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-4568","authenticated-orcid":false,"given":"Eivind W.","family":"Aabel","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation, Department of Cardiology Oslo University Hospital Oslo Norway"},{"name":"Institute for Clinical Medicine, University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-0541","authenticated-orcid":false,"given":"Anneli","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-1796","authenticated-orcid":false,"given":"Pia","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-1496","authenticated-orcid":false,"given":"Alex H\u00f8rby","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Herlev\u2010Gentofte Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-9040","authenticated-orcid":false,"given":"Tiina","family":"Heli\u00f6","sequence":"additional","affiliation":[{"name":"Heart and Lung Center Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8461-4496","authenticated-orcid":false,"given":"Aevar","family":"Ulfarsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-765X","authenticated-orcid":false,"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation, Department of Cardiology Oslo University Hospital Oslo Norway"},{"name":"Institute for Clinical Medicine, University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-8515","authenticated-orcid":false,"given":"Jesper H.","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4302","authenticated-orcid":false,"given":"Henrik K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine and Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina H.","family":"Haugaa","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation, Department of Cardiology Oslo University Hospital Oslo Norway"},{"name":"Institute for Clinical Medicine, University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8717","authenticated-orcid":false,"given":"Pyotr G.","family":"Platonov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv340"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq025"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12947"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60256-7"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12062"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.007"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542-474X.2003.08204.x"},{"key":"e_1_3_1_9_2","first-page":"73","volume-title":"Current Concepts in Arrhythmogenic Cardiomyopathy","author":"Bourfiss M","year":"2021","unstructured":"Bourfiss M, Hauer R. Current challenges in the diagnosis of arrhythmogenic cardiomyopathies. In: Brunckhorst C, Saguner AM, Duru F, eds Current Concepts in Arrhythmogenic Cardiomyopathy. 2nd ed. Cardiotext Publishing; 2021:73\u201387.","edition":"2"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.07.086"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu109"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X10666140514102928"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa039"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.10.005"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv063"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.05.095"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00062-4"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac267"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12285"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.988287"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T04:45:18Z","timestamp":1741409118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":19,"alternative-id":["10.1161\/JAHA.124.037544"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037544","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037544"}}