{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:35:15Z","timestamp":1789644915970,"version":"4.0.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Right ventricular failure (RVF) after left ventricular assist devices is associated with significant morbidity and mortality. Therefore, identifying patients at risk for severe RVF is important for clinical decision\u2010making. Current risk prediction models were not developed in contemporary populations with left ventricular assist devices and have limited clinical applicability. In this study, we sought to evaluate whether the Model for End Stage Liver Disease Excluding International Normalized Ratio (MELD\u2010XI) can predict severe RVF after HeartMate 3 implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed all adult patients who received HeartMate 3 left ventricular assist devices as initial implantation at 2 academic medical centers. We assessed whether MELD\u2010XI is an independent risk factor for severe RVF in multivariate analysis and compared the predictive accuracy of MELD\u2010XI with previously published risk scores. We also investigated the relationship between MELD\u2010XI and markers of RV function and whether MELD\u2010XI was associated with death or pump exchange at 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Our study included a total of 246 patients, of whom 74 (30%) experienced severe RVF. After adjusting for relevant covariables, MELD\u2010XI was independently associated with severe RVF (odds ratio [OR], 1.18 [95% CI, 1.09\u20131.29];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and performed similarly to the EUROMACS (European Registry for Patients with Mechanical Circulatory Support) and Michigan RVF risk scores. In addition, MELD\u2010XI was not reflective of traditional echocardiographic or hemodynamic measures of right ventricular function. Finally, MELD\u2010XI \u226514 predicted worse in\u2010hospital mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients undergoing HeartMate 3implantation, MELD\u2010XI is independently associated with an increased risk of RVF and in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037553","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T06:00:44Z","timestamp":1743055244000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Model for End Stage Liver Disease Excluding International Normalized Ratio Predicts Severe Right Ventricular Failure After HeartMate 3 Implantation in a Contemporary Cohort"],"prefix":"10.1161","volume":"14","author":[{"given":"David S.","family":"Lambert","sequence":"first","affiliation":[{"name":"Washington University School of Medicine in St. Louis","place":["Saint Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Pic\u00f3","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis","place":["Saint Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-3579","authenticated-orcid":false,"given":"Elena","family":"Deych","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis","place":["Saint Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-9031","authenticated-orcid":false,"given":"Erin","family":"Coglianese","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital\/Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-1994","authenticated-orcid":false,"given":"Joel D.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis","place":["Saint Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-3437","authenticated-orcid":false,"given":"Justin M.","family":"Vader","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis","place":["Saint Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-145X","authenticated-orcid":false,"given":"Bin Q.","family":"Yang","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital\/Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900486"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.10.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.1362"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.11.026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.09.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.099"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030543"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94792-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.006994"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50062"},{"key":"e_1_3_2_14_2","first-page":"87","article-title":"Heart failure and liver disease: cardiohepatic interactions","volume":"7","author":"Xanthopoulos A","year":"2019","unstructured":"Xanthopoulos A, Starling RC, Kitai T, Triposkiadis F. Heart failure and liver disease: cardiohepatic interactions. J Am Coll Cardiol Heart Fail. 2019;7:87\u201397.","journal-title":"J Am Coll Cardiol Heart Fail"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20906"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14046"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.07.029"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.02.082"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002050"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.06.009"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.10.019"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.02.012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.11.001"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.09.006"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.07.022"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001127"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4909"},{"key":"e_1_3_2_28_2","first-page":"420","article-title":"Changes in use of left ventricular assist devices as bridge to transplantation with new heart allocation policy","volume":"2021","author":"Mullan CW","year":"2021","unstructured":"Mullan CW, Chouairi F, Sen S, Mori M, Clark KAA, Reinhardt SW, Miller PE, Fuery MA, Jacoby D, Maulion C, et\u00a0al. Changes in use of left ventricular assist devices as bridge to transplantation with new heart allocation policy. J Am Coll Cardiol Heart Fail. 2021;2021:420\u2013429.","journal-title":"J Am Coll Cardiol Heart Fail"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.07.008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.005"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.12.017"},{"key":"e_1_3_2_32_2","first-page":"948","article-title":"Prediction of survival after implantation of a fully magnetically levitated left ventricular assist device","volume":"10","author":"Mehra MR","year":"2022","unstructured":"Mehra MR, Nayak A, Morris AA, Lanfear DE, Nemeh H, Desai S, Bansal A, Guerrero\u2010Miranda C, Hall S, Cleveland JC Jr, et\u00a0al. Prediction of survival after implantation of a fully magnetically levitated left ventricular assist device. J Am Coll Cardiol Heart Fail. 2022;10:948\u2013959.","journal-title":"J Am Coll Cardiol Heart Fail"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.02.011"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.838656"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.027"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000560"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2207410"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.123.010478"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:38:35Z","timestamp":1763991515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1161\/JAHA.124.037553"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037553","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037553"}}