{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:36:50Z","timestamp":1781739410259,"version":"3.54.5"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Disopyramide is used to treat heart failure symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM) with known medium\u2010term efficacy and safety, while long\u2010term outcomes are unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 92 consecutive patients with symptomatic obstructive HCM with peak left ventricular outflow tract gradients of \u226530\u2009mm\u2009Hg at rest or with provocation who were maintained on disopyramide for \u22655\u2009years at 2 dedicated HCM centers were included: 92 patients; mean age, 62.5\u2009years; 54% women; treated with disopyramide for median 7.2\u2009years (left ventricular wall thickness 18\u00b14\u2009mm; median peak outflow gradient 95\u2009mm\u2009Hg). At last follow\u2010up, 62 (67%) patients continued disopyramide, including 57 with symptom improvement \u22651 New York Heart Association class. The other 30 (33%) patients discontinued disopyramide due primarily to incomplete symptom resolution and required surgical myectomy or alcohol septal ablation (n=23) at 7.4\u2009years from initiation. With disopyramide, resting left ventricular outflow gradients were reduced by 37% (to median 19\u2009mm\u2009Hg), and provoked gradients decreased by 57% (to median 41\u2009mm\u2009Hg), with no residual outflow obstruction (&lt;30\u2009mm\u2009Hg at rest or with provocation) in 42 (46%) patients and no change in ejection fraction (69%\u00b16% versus 69%\u00b19%,\n              <jats:italic>P<\/jats:italic>\n              =0.51). Ventricular tachyarrhythmias and left ventricular systolic dysfunction were uncommon (n=3 and n=1) and were not attributed to disopyramide. Death on disopyramide was exceedingly rare (n=3 [5%]) and non\u2013HCM\u2010related occurring at age \u226590\u2009years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with obstructive HCM, disopyramide is safe and effective at relieving heart failure symptoms from outflow obstruction in a subgroup of patients who were maintained on disopyramide for &gt;5\u2009years.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037639","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:43:28Z","timestamp":1737027808000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Disopyramide Revisited for Treatment of Symptomatic Obstructive Hypertrophic Cardiomyopathy: Efficacy and Safety in Patients Treated for at Least 5\u2009Years"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-6456","authenticated-orcid":false,"given":"Daniele","family":"Massera","sequence":"first","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-7780","authenticated-orcid":false,"given":"Mark V.","family":"Sherrid","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7240-6644","authenticated-orcid":false,"given":"Elizabeth","family":"Adlestein","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bokhari","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-2600","authenticated-orcid":false,"given":"Maria C.","family":"Reuter","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Program Leon H. Charney Division of Cardiology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-3853","authenticated-orcid":false,"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-8670","authenticated-orcid":false,"given":"Barry J.","family":"Maron","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-0143","authenticated-orcid":false,"given":"Ethan J.","family":"Rowin","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.021"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.04.005"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.065"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.012"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.04.003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.112.000122"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005152"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.06.004"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.040"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072725"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001250"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198210143071607"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae198"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31792-x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401424"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.3342"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.09.028"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.030607"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1188"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.032838"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4638"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.019978"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:04:14Z","timestamp":1737547454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,21]]}},"alternative-id":["10.1161\/JAHA.124.037639"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037639","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037639"}}